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http://hdl.handle.net/1942/37227
Title: | Defining the Recipe for an Optimal Rotavirus Vaccine Introduction in a High-Income Country in Europe | Authors: | STANDAERT, Baudouin Benninghoff, Bernd |
Issue Date: | 2022 | Publisher: | MDPI | Source: | Viruses-Basel, 14 (2) , p. 425 (Art N° 425) | Abstract: | Observational data over 15 years of rotavirus vaccine introduction in Belgium have indicated that rotavirus hospitalisations in children aged <5 years plateaued at a higher level than expected, and was followed by biennial disease peaks. The research objective was to identify factors influencing these real-world vaccine impact data. We constructed mathematical models simulating rotavirus-related hospitalisations by age group and year for those children. Two periods were defined using different model constructs. First, the vaccine uptake period encompassed the years required to cover the whole at-risk population. Second, the post-uptake period covered the years in which a new infection/disease equilibrium was reached. The models were fitted to the observational data using optimisation programmes with regression and differential equations. Modifying parameter values identified factors affecting the pattern of hospitalisations. Results indicated that starting vaccination well before the peak disease season in the first year and rapidly achieving high coverage was critical in maximising early herd effect and minimising secondary sources of infection. This, in turn, would maximise the reduction in hospitalisations and minimise the size and frequency of subsequent disease peaks. The analysis and results identified key elements to consider for countries initiating an optimal rotavirus vaccine launch programme. | Notes: | Standaert, B (corresponding author), HEBO Bv, B-2020 Antwerp, Belgium.; Standaert, B (corresponding author), Univ Hasselt, Fac Med & Life Sci, Res Grp Care & Eth, B-3500 Hasselt, Belgium. baudouin.standaert@skynet.be; bernd.benninghoff@gmx.de |
Keywords: | rotavirus vaccination; implementation; optimisation; high income;country; long-term effect | Document URI: | http://hdl.handle.net/1942/37227 | e-ISSN: | 1999-4915 | DOI: | 10.3390/v14020425 | ISI #: | WOS:000776367300001 | Rights: | Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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viruses-14-00425-v2.pdf | Published version | 3.07 MB | Adobe PDF | View/Open |
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