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Title: | Sensitivity and specificity of different exercise oscillatory ventilation definitions to predict 2-year major adverse cardiovascular outcomes in chronic heart failure patients | Authors: | Dos Santos Ribeiro, Gustavo Deresz, Luís Salvioni, Elisabetta HANSEN, Dominique Agostoni, Piergiuseppe Karsten, Marlus |
Issue Date: | 2022 | Publisher: | Source: | INTERNATIONAL JOURNAL OF CARDIOLOGY, 360 (2022) p. 39-45 | Status: | In press | Abstract: | Background: Exercise oscillatory ventilation (EOV) shows a four-fold greater risk of adverse events. This study aims to analyze the sensitivity and specificity of three EOV diagnostic definitions to predict adverse outcomes at a 2-year follow-up and to compare its EOV prevalence and relations with the patient's profile.Methods: Cardiopulmonary exercise tests from 233 heart failure patients were analyzed. Two blinded reviewers used a semiautomated software to identify EOV cases pattern according to the definitions of Ben-Dov, Corr`a, and Leite. Data were grouped in EOV-positive or EOV-negative according to each definition. Baseline characteristics, EOV prevalence, relative risk, sensitivity, and specificity to predict 2-years of major adverse cardiovascular outcomes were analyzed.Results: The Corra definition led to the best prediction of 2-year major cardiovascular adverse outcomes (HR 2.46 [1.16 to 5.25]; p = 0.019, AUC = 0.618; p = 0.007). EOV prevalence was 17.2%, 17.2%, and 9.4% applying BenDov, Corr`a, and Leite definition, respectively. The main clinical differences between EOV-positive and EOVnegative patients were: MECKI score and VE/VCO2 slope (all definitions), and BNP levels (Ben-Dov and Leite). BNP levels were correlated with amplitude (rho = 0.255; p = 0.033) and cycle length (rho = 0.388; p = 0.002).Conclusion: Corra definition was the only one that exhibited the capacity to predict major adverse cardiovascular outcomes at a 2-year follow-up. Regardless of its definition, EOV was more often prevalent in patients with a greater MECKI score and VE/VCO2 slope values. | Keywords: | Cardiology;Cardiovascular diseases;Cardiopulmonary exercise test;Periodic breathing;Prognosis | Document URI: | http://hdl.handle.net/1942/37331 | ISSN: | 0167-5273 | e-ISSN: | 1874-1754 | DOI: | 10.1016/j.ijcard.2022.05.041 | ISI #: | 000817715400009 | Rights: | © 2022 Elsevier B.V. All rights reserved | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Ribeiro et al. Int J Cardiol 2022 (1).pdf | Non Peer-reviewed author version | 901.15 kB | Adobe PDF | View/Open |
1-s2.0-S0167527322007537-main.pdf Restricted Access | Published version | 1.29 MB | Adobe PDF | View/Open Request a copy |
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