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Title: | Advancing tools for human early lifecourse exposome research and translation (ATHLETE) | Authors: | Vrijheid, Martine Basagana, Xavier Gonzalez, Juan R. Jaddoe, Vincent W. V. Jensen, Genon Keun, Hector C. McEachan, Rosemary R. C. Porcel, Joana Siroux, Valerie Swertz, Morris A. Thomsen, Cathrine Aasvang, Gunn Marit Andrusaityte, Sandra Angeli, Karine Avraam, Demetris Ballester, Ferran Burton, Paul Bustamante, Mariona Casas, Maribel Chatzi, Leda Chevrier, Cecile Cingotti, Natacha Conti, David Crepet, Amelie Dadvand, Payam Duijts, Liesbeth van Enckevort, Esther Esplugues, Ana Fossati, Serena Garlantezec, Ronan Gomez Roig, Maria Dolores Grazuleviciene, Regina Guetzkow, Kristine B. Guxens, Monica Haakma, Sido Hessel, Ellen V. S. Hoyles, Lesley Hyde, Eleanor Klanova, Jana van Klaveren, Jacob D. Kortenkamp, Andreas Le Brusquet, Laurent Leenen, Ivonne Lertxundi, Aitana Lertxundi, Nerea Lionis, Christos Llop, Sabrina Lopez-Espinosa, Maria-Jose Lyon-Caen, Sarah Maitre, Lea Mason, Dan Mathy, Sandrine Mazarico, Edurne NAWROT, Tim Nieuwenhuijsen, Mark Ortiz, Rodney Pedersen, Marie Perello, Josep Perez-Cruz, Miriam Philippat, Claire Piler, Pavel Pizzi, Costanza Quentin, Joane Richiardi, Lorenzo RODRIGUEZ, Adrian Roumeliotaki, Theano Sabin Capote, Jose Manuel Santiago, Leonardo Santos, Susana Siskos, Alexandros P. Strandberg-Larsen, Katrine Stratakis, Nikos Sunyer, Jordi Tenenhaus, Arthur Vafeiadi, Marina Wilson, Rebecca C. Wright, John YANG, Tiffany Slama, Remy |
Issue Date: | 2021 | Publisher: | LIPPINCOTT WILLIAMS & WILKINS | Source: | Environmental Epidemiology, 5 (5) (Art N° e166) | Abstract: | Early life stages are vulnerable to environmental hazards and present important windows of opportunity for lifelong disease prevention. This makes early life a relevant starting point for exposome studies. The Advancing Tools for Human Early Lifecourse Exposome Research and Translation (ATHLETE) project aims to develop a toolbox of exposome tools and a Europe-wide exposome cohort that will be used to systematically quantify the effects of a wide range of community- and individual-level environmental risk factors on mental, cardiometabolic, and respiratory health outcomes and associated biological pathways, longitudinally from early pregnancy through to adolescence. Exposome tool and data development include as follows: (1) a findable, accessible, interoperable, reusable (FAIR) data infrastructure for early life exposome cohort data, including 16 prospective birth cohorts in 11 European countries; (2) targeted and nontargeted approaches to measure a wide range of environmental exposures (urban, chemical, physical, behavioral, social); (3) advanced statistical and toxicological strategies to analyze complex multidimensional exposome data; (4) estimation of associations between the exposome and early organ development, health trajectories, and biological (metagenomic, metabolomic, epigenetic, aging, and stress) pathways; (5) intervention strategies to improve early life urban and chemical exposomes, co-produced with local communities; and (6) child health impacts and associated costs related to the exposome. Data, tools, and results will be assembled in an openly accessible toolbox, which will provide great opportunities for researchers, policy-makers, and other stakeholders, beyond the duration of the project. ATHLETE'S results will help to better understand and prevent health damage from environmental exposures and their mixtures from the earliest parts of the life course onward. | Notes: | Vrijheid, M (corresponding author), Inst Global Hlth, ISGlobal, C Doctor Aiguader 88, Barcelona 08003, Spain. martine.vrijheid@isglobal.org |
Keywords: | Exposome;Early life;Exposure assessment;Child health;Adolescent health | Document URI: | http://hdl.handle.net/1942/37473 | e-ISSN: | 2474-7882 | DOI: | 10.1097/EE9.0000000000000166 | ISI #: | WOS:000784742100005 | Rights: | © 2021 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The Environmental Epidemiology. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. | Category: | A1 | Type: | Journal Contribution | Validations: | vabb 2024 |
Appears in Collections: | Research publications |
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