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http://hdl.handle.net/1942/37538
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DC Field | Value | Language |
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dc.contributor.author | STASSEN, Jan | - |
dc.contributor.author | Khidir, Mand | - |
dc.contributor.author | Galloo, Xavier | - |
dc.contributor.author | Hirasawa, Kensuke | - |
dc.contributor.author | Knuuti, Juhani | - |
dc.contributor.author | Marsan, Nina Ajmone | - |
dc.contributor.author | Delgado, Victoria | - |
dc.contributor.author | van der Bijl, Pieter | - |
dc.contributor.author | Bax, Jeroen J. | - |
dc.date.accessioned | 2022-06-20T08:15:39Z | - |
dc.date.available | 2022-06-20T08:15:39Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-06-01T13:59:33Z | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF CARDIOLOGY, 355 , p. 65 -71 | - |
dc.identifier.uri | http://hdl.handle.net/1942/37538 | - |
dc.description.abstract | Background: Cardiac resynchronization therapy (CRT) candidates often present with significant mitral and tricuspid regurgitation, pulmonary hypertension and right ventricular dysfunction when referred for device implantation. This study investigated the prognostic value of a novel cardiac staging system, based on the extent of cardiac remodeling prior to implantation.Methods: Data were collected from an ongoing registry of CRT recipients. Patients were divided into 4 groups according to the extent of cardiac remodeling: group 1: left ventricular systolic dysfunction, group 2: left atrial dilatation and/or significant mitral regurgitation, group 3: pulmonary arterial hypertension and/or significant tricuspid regurgitation and group 4: right ventricular systolic impairment. Patients were followed up for the occurrence of all-cause mortality.Results: A total of 844 patients (age 65 +/-& nbsp;10 years, 77% men) were included. Of the overall population, 145 (17%) patients were in group 1, 161 (19%) in group 2, 157 (19%) in group 3 and 381 (45%) in group 4. After a median follow-up of 95 (51-145) months, 517 (61%) patients died. Patients in groups 2, 3 and 4 had significantly higher mortality rates than those in group 1 (p = 0.025, p < 0.001 and p < 0.001, respectively). On multivariable analysis, groups 3 (HR 1.415; 95% CI 1.024-1.957; p = 0.032) and 4 (HR 1.599; 95% CI 1.204-2.123; p = 0.001) were independently associated with all-cause mortality.Conclusions: Most CRT candidates already present with extensive cardiac remodeling at the time of referral. Detection of the extent of cardiac remodeling before CRT implantation results in improved risk-stratification, and underscores the need for early referral. | - |
dc.description.sponsorship | The Department of Cardiology, Heart Lung Center, Leiden University Medical Centre received research grants from Abbott Vascular, Bayer, Biotronik, Bioventrix, Boston Scientific, Edwards Lifesciences, GE Healthcare, Ionis and Medtronic. JJB received speaker fees from Abbott Vascular. NAM received speaker fees from Abbott Vascular and GE Healthcare. VD received speaker fees from Abbott Vascular, Edwards Lifesciences, GE Healthcare, Medtronic, MSD and Novartis. The remaining authors have nothing to disclose | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.rights | 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) | - |
dc.subject.other | Heart failure with reduced ejection fraction | - |
dc.subject.other | Cardiac resynchronization therapy | - |
dc.subject.other | Cardiac remodeling | - |
dc.subject.other | Mortality | - |
dc.title | Prognostic implications of staging cardiac remodeling in patients undergoing cardiac resynchronization therapy | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 71 | - |
dc.identifier.spage | 65 | - |
dc.identifier.volume | 355 | - |
local.format.pages | 7 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Bax, JJ (corresponding author), Heart Lung Ctr, Dept Cardiol, Albinusdreef 2, NL-2300 RC Leiden, Netherlands. | - |
dc.description.notes | j.j.bax@lumc.nl | - |
local.publisher.place | ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.ijcard.2022.02.020 | - |
dc.identifier.pmid | 35189167 | - |
dc.identifier.isi | WOS:000794878100017 | - |
dc.contributor.orcid | Stassen, Jan/0000-0001-9745-5498 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Stassen, Jan; Khidir, Mand; Galloo, Xavier; Hirasawa, Kensuke; Knuuti, Juhani; Marsan, Nina Ajmone; Delgado, Victoria; van der Bijl, Pieter; Bax, Jeroen J.] Leiden Univ, Med Ctr, Dept Cardiol, Albinusdreef 2, NL-2300 RC Leiden, Netherlands. | - |
local.description.affiliation | [Stassen, Jan] Jessa Hosp Hasselt, Dept Cardiol, Stadsomvaart 11, B-3500 Hasselt, Belgium. | - |
local.description.affiliation | [Galloo, Xavier] Univ Ziekenhuis Brussel UZ Brussel, Vrije Univ Brussel VUB, Dept Cardiol, Laarbeeklaan 101, B-1090 Brussels, Belgium. | - |
local.description.affiliation | [Knuuti, Juhani] Univ Turku, Turku PET Ctr, Kunamyllynkatu 4-8, FI-20520 Turku, Finland. | - |
local.description.affiliation | [Knuuti, Juhani; Bax, Jeroen J.] Turku Univ Hosp, Kunamyllynkatu 4-8, FI-20520 Turku, Finland. | - |
local.description.affiliation | [Bax, Jeroen J.] Univ Turku, Turku Heart Ctr, Kunamyllynkatu 4-8, FI-20520 Turku, Finland. | - |
local.uhasselt.international | yes | - |
item.fullcitation | STASSEN, Jan; Khidir, Mand; Galloo, Xavier; Hirasawa, Kensuke; Knuuti, Juhani; Marsan, Nina Ajmone; Delgado, Victoria; van der Bijl, Pieter & Bax, Jeroen J. (2022) Prognostic implications of staging cardiac remodeling in patients undergoing cardiac resynchronization therapy. In: INTERNATIONAL JOURNAL OF CARDIOLOGY, 355 , p. 65 -71. | - |
item.fulltext | With Fulltext | - |
item.contributor | STASSEN, Jan | - |
item.contributor | Khidir, Mand | - |
item.contributor | Galloo, Xavier | - |
item.contributor | Hirasawa, Kensuke | - |
item.contributor | Knuuti, Juhani | - |
item.contributor | Marsan, Nina Ajmone | - |
item.contributor | Delgado, Victoria | - |
item.contributor | van der Bijl, Pieter | - |
item.contributor | Bax, Jeroen J. | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 0167-5273 | - |
crisitem.journal.eissn | 1874-1754 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Prognostic implications of staging cardiac remodeling in patients undergoing cardiac resynchronization therapy.pdf | Published version | 1.09 MB | Adobe PDF | View/Open |
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