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Title: | Prognostic implications of staging cardiac remodeling in patients undergoing cardiac resynchronization therapy | Authors: | STASSEN, Jan Khidir, Mand Galloo, Xavier Hirasawa, Kensuke Knuuti, Juhani Marsan, Nina Ajmone Delgado, Victoria van der Bijl, Pieter Bax, Jeroen J. |
Issue Date: | 2022 | Publisher: | ELSEVIER IRELAND LTD | Source: | INTERNATIONAL JOURNAL OF CARDIOLOGY, 355 , p. 65 -71 | Abstract: | Background: Cardiac resynchronization therapy (CRT) candidates often present with significant mitral and tricuspid regurgitation, pulmonary hypertension and right ventricular dysfunction when referred for device implantation. This study investigated the prognostic value of a novel cardiac staging system, based on the extent of cardiac remodeling prior to implantation.Methods: Data were collected from an ongoing registry of CRT recipients. Patients were divided into 4 groups according to the extent of cardiac remodeling: group 1: left ventricular systolic dysfunction, group 2: left atrial dilatation and/or significant mitral regurgitation, group 3: pulmonary arterial hypertension and/or significant tricuspid regurgitation and group 4: right ventricular systolic impairment. Patients were followed up for the occurrence of all-cause mortality.Results: A total of 844 patients (age 65 +/-& nbsp;10 years, 77% men) were included. Of the overall population, 145 (17%) patients were in group 1, 161 (19%) in group 2, 157 (19%) in group 3 and 381 (45%) in group 4. After a median follow-up of 95 (51-145) months, 517 (61%) patients died. Patients in groups 2, 3 and 4 had significantly higher mortality rates than those in group 1 (p = 0.025, p < 0.001 and p < 0.001, respectively). On multivariable analysis, groups 3 (HR 1.415; 95% CI 1.024-1.957; p = 0.032) and 4 (HR 1.599; 95% CI 1.204-2.123; p = 0.001) were independently associated with all-cause mortality.Conclusions: Most CRT candidates already present with extensive cardiac remodeling at the time of referral. Detection of the extent of cardiac remodeling before CRT implantation results in improved risk-stratification, and underscores the need for early referral. | Notes: | Bax, JJ (corresponding author), Heart Lung Ctr, Dept Cardiol, Albinusdreef 2, NL-2300 RC Leiden, Netherlands. j.j.bax@lumc.nl |
Keywords: | Heart failure with reduced ejection fraction;Cardiac resynchronization therapy;Cardiac remodeling;Mortality | Document URI: | http://hdl.handle.net/1942/37538 | ISSN: | 0167-5273 | e-ISSN: | 1874-1754 | DOI: | 10.1016/j.ijcard.2022.02.020 | ISI #: | WOS:000794878100017 | Rights: | 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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Prognostic implications of staging cardiac remodeling in patients undergoing cardiac resynchronization therapy.pdf | Published version | 1.09 MB | Adobe PDF | View/Open |
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