Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/37552
Title: Telomere length in individuals with and without major depression and adverse childhood experiences
Authors: Kuehl, L.K.
De Punder, K
Deuter, C.E.
MARTENS, Dries 
Heim, C.
OTT, C.
Wingenfeld, K.
Entringer, S.
Issue Date: 2022
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Source: PSYCHONEUROENDOCRINOLOGY, 142 (Art N° 105762)
Abstract: Major depressive disorder (MDD) and adverse childhood experiences (ACE) are associated with poor physical and mental health in adulthood. One underlying mechanism might be accelerated cellular aging. For example, both conditions, MDD and ACE, have been related to a biological marker of cellular aging, accelerated shortening of telomere length (TL). Since MDD and ACE are confounded in many studies, we aimed with the current study to further disentangle the effects of MDD and ACE on TL using a full-factorial design including four carefully diagnosed groups of healthy participants and MDD patients with and without ACE (total N = 90, all without use of antidepressants). As dependent variable, TL was assessed in leukocytes. We found no group differences based on MDD and ACE exposure in TL. While TL was negatively associated with age and male sex, TL was not associated with any measure of severity of MDD, ACE or current stress. One possible explanation for our null result may be the comparatively good physical health status of our sample. Future research is needed to elucidate the relation of TL, MDD and ACE, taking potential effect modification by medication intake and physical health status into account
Keywords: Telomere length;Major depressive disorder;Childhood trauma;Early life stress;Stress
Document URI: http://hdl.handle.net/1942/37552
ISSN: 0306-4530
e-ISSN: 1873-3360
DOI: 10.1016/j.psyneuen.2022.105762
ISI #: 000818071100010
Category: A1
Type: Journal Contribution
Validations: ecoom 2023
Appears in Collections:Research publications

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