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Title: | Cardiovascular Profile of South African Adults with Low-Level Viremia during Antiretroviral Therapy | Authors: | Botha-Le Roux, Shani Elvstam, Olof DE BOEVER, Patrick Goswami, Nandu Magnusson, Martin Nilsson, Peter M. Strijdom, Hans Bjorkman, Per Fourie, Carla M. T. |
Issue Date: | 2022 | Publisher: | MDPI | Source: | Journal of Clinical Medicine, 11 (10) (Art N° 2812) | Abstract: | Chronic inflammation is an HIV infection feature, contributing to elevated risk of cardiovascular disease among people with HIV, which can be induced by viral replication. A proportion of antiretroviral therapy (ART) recipients fail to achieve viral suppression, despite not meeting criteria for treatment failure, so-called low-level viremia (LLV). We investigated the relationship between LLV and an array of cardiovascular measures and biomarkers. South Africans with LLV (viral load = 50-999 copies/mL) and virological suppression (viral load <50 copies/mL) were selected from the EndoAfrica study (all receiving efavirenz-based ART) for cross-sectional comparison of vascular structure and function measures, as well as 21 plasma biomarkers related to cardiovascular risk and inflammation. Associations were investigated with univariate, multivariate, and binomial logistic regression analyses (having outcome measures above (cases) or below (controls) the 75th percentile). Among 208 participants, 95 (46%) had LLV, and 113 (54%) had viral suppression. The median age was 44 years, 73% were women, and the median ART duration was 4.5 years. Cardiovascular measures and biomarker levels were similar between these two categories. Cardiovascular function and structure measures were not associated with viremia status and having LLV did not increase the odds of having outcome measures above the 75th percentile. In this study among South African ART recipients, LLV did not associate with cardiovascular risk. | Notes: | Botha-Le Roux, S (corresponding author), North West Univ, Hypertens Africa Res Team HART, ZA-2520 Potchefstroom, South Africa.; Botha-Le Roux, S (corresponding author), North West Univ, Med Res Council, Unit Hypertens & Cardiovasc Dis, ZA-2520 Potchefstroom, South Africa. shani.botha@nwu.ac.za; olof.elvstam@med.lu.se; patrick.deboever@uantwerpen.be; nandu.goswami@medunigraz.at; martin.magnusson@med.lu.se; peter.nilsson@med.lu.se; jgstr@sun.ac.za; per.bjorkman@med.lu.se; carla.fourie@nwu.ac.za |
Keywords: | biomarkers;blood vessels;cardiovascular disease;human immunodeficiency virus;viral load | Document URI: | http://hdl.handle.net/1942/37557 | e-ISSN: | 2077-0383 | DOI: | 10.3390/jcm11102812 | ISI #: | WOS:000802663600001 | Rights: | 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/) | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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