Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/37699
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dc.contributor.authorKoeck, Rebekka M.-
dc.contributor.authorBusato, Florence-
dc.contributor.authorTost, Jorg-
dc.contributor.authorConsten, Dimitri-
dc.contributor.authorVan Echten-Arends, Jannie-
dc.contributor.authorMastenbroek, Sebastiaan-
dc.contributor.authorWurth, Yvonne-
dc.contributor.authorRemy, Sylvie-
dc.contributor.authorLANGIE, Sabine-
dc.contributor.authorNAWROT, Tim-
dc.contributor.authorPLUSQUIN, Michelle-
dc.contributor.authorALFANO, Rossella-
dc.contributor.authorBIJNENS, Esmee-
dc.contributor.authorGielen , Marij-
dc.contributor.authorvan Golde, Ron-
dc.contributor.authorDumoulin, John C. M.-
dc.contributor.authorBrunner, Han-
dc.contributor.authorvan Montfoort, Aafke P. A.-
dc.contributor.authorEsteki, Masoud Zamani-
dc.date.accessioned2022-07-13T06:56:54Z-
dc.date.available2022-07-13T06:56:54Z-
dc.date.issued2022-
dc.date.submitted2022-07-07T10:03:36Z-
dc.identifier.citationnpj Genomic Medicine, 7 (1) (Art N° 39)-
dc.identifier.urihttp://hdl.handle.net/1942/37699-
dc.description.abstractA growing number of children born are conceived through in vitro fertilisation (IVF), which has been linked to an increased risk of adverse perinatal outcomes, as well as altered growth profiles and cardiometabolic differences in the resultant individuals. Some of these outcomes have also been shown to be influenced by the use of different IVF culture media and this effect is hypothesised to be mediated epigenetically, e.g. through the methylome. As such, we profiled the umbilical cord blood methylome of IVF neonates that underwent preimplantation embryo development in two different IVF culture media (G5 or HTF), using the Infinium Human Methylation EPIC BeadChip. We found no significant methylation differences between the two groups in terms of: (i) systematic differences at CpG sites or regions, (ii) imprinted sites/genes or birth weight-associated sites, (iii) stochastic differences presenting as DNA methylation outliers or differentially variable sites, and (iv) epigenetic gestational age acceleration.-
dc.description.sponsorshipWe thank the IVF couples who have agreed for their children to participate in this study. We thank all the employees of the IVF clinics and obstetrics departments involved in recruiting participants and collecting samples for this study. We thank E. Pishva for his consultation regarding data analysis and for the critical reading of the manuscript. This study was funded by March of Dimes (6-FY13-153). It was further supported by the stichting fertility foundation, EVA (Erfelijkheid Voortplanting & Aanleg) speciality programme (grant no. KP111513) of Maastricht University Medical Centre (MUMC+), and the Horizon 2020 innovation (ERIN) (grant no. EU952516) of the European Commission. We thank the FLEHS Supervisory Board for the provision of data. The FLEHS studies are commissioned, financed, and steered by the Flemish Government (Department of Economy, Science and Innovations, Agency for Care and Health and Department of Environment). The FLEHS dataset has been generated by the Flemish Center of Expertise on Environment and Health (FLEHS 2016–2020), funded by the Environment, Nature and Energy Department of the Flemish government. The views expressed in this manuscript are those of the author(s) and are not necessarily endorsed by the Flemish government.-
dc.language.isoen-
dc.publisherNATURE PORTFOLIO-
dc.rightsThe Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http:// creativecommons.org/licenses/by/4.0/.-
dc.titleMethylome-wide analysis of IVF neonates that underwent embryo culture in different media revealed no significant differences-
dc.typeJournal Contribution-
dc.identifier.issue1-
dc.identifier.volume7-
local.bibliographicCitation.jcatA1-
dc.description.notesEsteki, MZ (corresponding author), Maastricht Univ, Med Ctr, Dept Clin Genet, Maastricht, Netherlands.; Esteki, MZ (corresponding author), Maastricht Univ, Med Ctr, Dept Epidemiol, Maastricht, Netherlands.; Esteki, MZ (corresponding author), Maastricht Univ, Med Ctr, Nutr & Toxicol Res Inst Maastricht NUTRIM, Maastricht, Netherlands.; van Montfoort, APA (corresponding author), Maastricht Univ, Med Ctr, GROW Sch Oncol & Reprod, Dept Obstet & Gynaecol, Maastricht, Netherlands.-
dc.description.notesaafke.van.montfoort@mumc.nl; masoud.zamaniesteki@mumc.nl-
local.publisher.placeHEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.artnr39-
dc.identifier.doi10.1038/s41525-022-00310-3-
dc.identifier.pmid35768464-
dc.identifier.isiWOS:000818814800001-
dc.contributor.orcidMastenbroek, Sebastiaan/0000-0002-7550-2924-
local.provider.typewosris-
local.description.affiliation[Koeck, Rebekka M.; Brunner, Han; Esteki, Masoud Zamani] Maastricht Univ, Med Ctr, Dept Clin Genet, Maastricht, Netherlands.-
local.description.affiliation[Koeck, Rebekka M.] Maastricht Univ, GROW Sch Oncol & Reprod, Dept Genet & Cell Biol, Maastricht, Netherlands.-
local.description.affiliation[Busato, Florence; Tost, Jorg] Univ Paris Saclay, CEA, Ctr Natl Rech Genom Humaine, Inst Biol Francois Jacob,Lab Epigenet & Environm, F-91000 Evry, France.-
local.description.affiliation[Consten, Dimitri; Wurth, Yvonne] St Elisabeth TweeSteden Hosp, Ctr Reprod Med, Hilvarenbeekseweg 60, NL-5022 GC Tilburg, Netherlands.-
local.description.affiliation[Van Echten-Arends, Jannie] Univ Groningen, Univ Med Ctr Groningen, Dept Obstet & Gynecol, Sect Reprod Med, Hanzepl 1, NL-9713 GZ Groningen, Netherlands.-
local.description.affiliation[Mastenbroek, Sebastiaan] Univ Amsterdam, Amsterdam UMC, Amsterdam Reprod & Dev Res Inst, Ctr Reprod Med, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.-
local.description.affiliation[Remy, Sylvie; Langie, Sabine] Flemish Inst Technol Res VITO, Hlth Unit, Boeretang 200, B-2400 Mol, Belgium.-
local.description.affiliation[Langie, Sabine] Maastricht Univ, Sch Nutr & Translat Res Metab NUTRIM, Dept Pharmacol & Toxicol, Maastricht, Netherlands.-
local.description.affiliation[Nawrot, Tim S.; Plusquin, Michelle; Alfano, Rossella; Bijnens, Esmee M.] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium.-
local.description.affiliation[Nawrot, Tim S.] Leuven Univ, KU Leuven, Dept Publ Hlth & Primary Care, Leuven, Belgium.-
local.description.affiliation[Bijnens, Esmee M.] Ghent Univ Hosp, Dept Human Struct & Repair, Ghent, Belgium.-
local.description.affiliation[Gielen, Marij; Esteki, Masoud Zamani] Maastricht Univ, Med Ctr, Dept Epidemiol, Maastricht, Netherlands.-
local.description.affiliation[Gielen, Marij; Esteki, Masoud Zamani] Maastricht Univ, Med Ctr, Nutr & Toxicol Res Inst Maastricht NUTRIM, Maastricht, Netherlands.-
local.description.affiliation[van Golde, Ron; Dumoulin, John C. M.; van Montfoort, Aafke P. A.] Maastricht Univ, Med Ctr, GROW Sch Oncol & Reprod, Dept Obstet & Gynaecol, Maastricht, Netherlands.-
local.description.affiliation[Brunner, Han] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, Nijmegen, Netherlands.-
local.uhasselt.internationalyes-
item.fulltextWith Fulltext-
item.fullcitationKoeck, Rebekka M.; Busato, Florence; Tost, Jorg; Consten, Dimitri; Van Echten-Arends, Jannie; Mastenbroek, Sebastiaan; Wurth, Yvonne; Remy, Sylvie; LANGIE, Sabine; NAWROT, Tim; PLUSQUIN, Michelle; ALFANO, Rossella; BIJNENS, Esmee; Gielen , Marij; van Golde, Ron; Dumoulin, John C. M.; Brunner, Han; van Montfoort, Aafke P. A. & Esteki, Masoud Zamani (2022) Methylome-wide analysis of IVF neonates that underwent embryo culture in different media revealed no significant differences. In: npj Genomic Medicine, 7 (1) (Art N° 39).-
item.accessRightsOpen Access-
item.validationecoom 2023-
item.contributorKoeck, Rebekka M.-
item.contributorBusato, Florence-
item.contributorTost, Jorg-
item.contributorConsten, Dimitri-
item.contributorVan Echten-Arends, Jannie-
item.contributorMastenbroek, Sebastiaan-
item.contributorWurth, Yvonne-
item.contributorRemy, Sylvie-
item.contributorLANGIE, Sabine-
item.contributorNAWROT, Tim-
item.contributorPLUSQUIN, Michelle-
item.contributorALFANO, Rossella-
item.contributorBIJNENS, Esmee-
item.contributorGielen , Marij-
item.contributorvan Golde, Ron-
item.contributorDumoulin, John C. M.-
item.contributorBrunner, Han-
item.contributorvan Montfoort, Aafke P. A.-
item.contributorEsteki, Masoud Zamani-
crisitem.journal.eissn2056-7944-
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