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Title: The MUC5B Promoter Polymorphism is Not Associated With Non-ILD Chronic Respiratory Diseases or Post-transplant Outcome
Authors: Goos, Tinne
Verleden, Stijn
De Sadeleer, Laurens
Van Herck, Anke
Sacreas, Annelore
Vanstapel, Arno
KAES, Janne 
Geudens, Vincent
Aelbrecht, Celine
Lambrechts, Diether
Vermeer, Sascha
Ceulemans, Laurens
Raemdonck, Dirk
Godinas, Laurent
Yserbyt, Jonas
Vanaudenaerde, Bart
Verleden, Geert
Vos, Robin
Wuyts, Wim
Issue Date: 2022
Source: Transplant international, 35 (Art N° 10159)
Abstract: The MUC5B promoter polymorphism (rs35705950) has been associated with interstitial lung disease (ILD) and with prolonged pre-transplant survival in idiopathic pulmonary fibrosis (IPF), but no information is available regarding its prevalence in other respiratory diseases and its influence on post-transplant outcome. We included the Leuven lung transplantation cohort between 1991 and 2015 (n = 801). We assessed the minor allele frequency (MAF) of the MUC5B variant in the entire study cohort and investigated the influence of recipient MUC5B promoter polymorphism on post-transplant outcome in patients who were transplanted after 2004. MUC5B was successfully genotyped in 746 patients. The MAF was significantly higher in ILD (17.6%) compared to chronic obstructive pulmonary disease (COPD)/emphysema (9.3%), cystic fibrosis (CF)/bronchiectasis (BRECT) (7.5%) and pulmonary hypertension (PHT) (7.4%) (p < 0.001). No association was observed between rs35705950 and chronic lung allograft dysfunction (CLAD)/graft loss in the ILD population [CLAD: HR 1.37 95% CI (0.70-2.68); graft loss: HR 1.02 95% CI (0.55-1.89)], nor the entire study cohort [CLAD: HR 0.96 95% CI (0.69-1.34); graft loss: HR 0.97 95% CI (0.70-1.35)]. The MUC5B promoter polymorphism is a very specific predictive factor for the presence of pulmonary fibrosis
Keywords: Abbreviations: AR, acute rejection;AZA, azathioprine;BRECT, bronchiectasis;CF, cystic fibrosis;cHP, chronic hypersen- sitivity pneumonitis;CI, confidence interval;CLAD, chronic lung allograft dysfunction;CMV, cytomegalovirus;COPD,
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ISSN: 0934-0874
e-ISSN: 1432-2277
DOI: 10.3389/ti.2022.10159
ISI #: 000822657800001
Category: A1
Type: Journal Contribution
Appears in Collections:Research publications

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