Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/37806
Title: | Hospital-acquired infections after acute ischaemic stroke and its association with healthcare-related costs and functional outcome | Authors: | Grieten, Jef Chevalier, Pierre Lesenne, Anouk Ernon, Ludovic Vandermeulen , Elly Panis , Elke MESOTTEN, Dieter |
Issue Date: | 2022 | Publisher: | SPRINGER HEIDELBERG | Source: | Acta neurologica belgica, 122 (5), p. 1281-1287 | Abstract: | Introduction Acute ischaemic stroke is associated with important mortality, morbidity, and healthcare-related costs. Age, pre-stroke functionality and stroke severity are important contributors to functional outcome. Stroke patients also risk developing infections during hospitalization. We sought to explore possible predictors of post-stroke infections and the relationship of post-stroke infection with healthcare-related costs and functional outcome. Methods This single-centre retrospective study included 530 patients treated for ischaemic stroke between January 2017 and February 2019. Antibiotics' administration was used as a proxy for post-stroke infection. Functional outcome at 90 days was assessed by the modified Rankin Scale (mRS). Total healthcare-related costs were recorded for the index hospital stay. Multivariable analysis for post-stroke infection was done with the independent factors sex, age, pre-stroke mRS, National Institutes of Health Stroke Scale (NIHSS) and diabetes mellitus. Results Twenty percent of patients had a post-stroke infection. NIHSS (OR 1.10, 95%CI 1.06-1.13, p < 0.0001) and diabetes mellitus (OR 2.18, 95%CI 1.28-3.71, p = 0.0042) were independent predictors for post-stroke infection. Mean total healthcare-related costs were 15,374 euro (SD 19,968; IQR 3,380-18,165), with a mean of 31,061 euro (SD 29,995; IQR 12,584-42,843) in patients with infection, compared to 11,406 euro (SD 13,987; IQR 3,083-12,726) in patients without (p < 0.0001). Median 90-days mRS was 5 (IQR 3-6) in patients with infection versus 1 (IQR 0-3.5) in patients without (p < 0.0001). Conclusions In patients, admitted for acute ischaemic stroke, stroke severity and diabetes mellitus were identified as the main predictors for post-stroke infection. Hospital-acquired infections were associated with increased costs and worse functional outcome. | Notes: | Mesotten, D (corresponding author), ZOL Genk, Crit Care Dept, Dept Anaesthesiol & Intens Care Med, Schiepse Bos 6, B-3600 Genk, Belgium.; Mesotten, D (corresponding author), Hasselt Univ, Fac Med & Life Sci, Diepenbeek, Belgium. dieter.mesotten@zol.be |
Keywords: | Cerebrovascular disorders;Stroke;Infection;Costs | Document URI: | http://hdl.handle.net/1942/37806 | ISSN: | 0300-9009 | e-ISSN: | 2240-2993 | DOI: | 10.1007/s13760-022-01977-2 | ISI #: | 000819276000001 | Rights: | The Author(s) under exclusive licence to Belgian Neurological Society 2022 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
s13760-022-01977-2.pdf Restricted Access | Published version | 563.49 kB | Adobe PDF | View/Open Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.