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Title: | Innate Lymphoid Cells-Neglected Players in Multiple Sclerosis | Authors: | Hassanabadi, Negar Sadeghi BROUX, Bieke Marinovic, Sonja Gotthardt, Dagmar |
Issue Date: | 2022 | Publisher: | FRONTIERS MEDIA SA | Source: | Frontiers in immunology, 13 (Art N° 909275) | Abstract: | Multiple sclerosis (MS) is a highly debilitating autoimmune disease affecting millions of individuals worldwide. Although classically viewed as T-cell mediated disease, the role of innate lymphoid cells (ILC) such as natural killer (NK) cells and ILC 1-3s has become a focal point as several findings implicate them in the disease pathology. The role of ILCs in MS is still not completely understood as controversial findings have been reported assigning them either a protective or disease-accelerating role. Recent findings in experimental autoimmune encephalomyelitis (EAE) suggest that ILCs infiltrate the central nervous system (CNS), mediate inflammation, and have a disease exacerbating role by influencing the recruitment of autoreactive T-cells. Elucidating the detailed role of ILCs and altered signaling pathways in MS is essential for a more complete picture of the disease pathology and novel therapeutic targets. We here review the current knowledge about ILCs in the development and progression of MS and preclinical models of MS and discuss their potential for therapeutic applications. | Notes: | Gotthardt, D (corresponding author), Univ Vet Med Vienna, Inst Pharmacol & Toxicol, Vienna, Austria. dagmar.gotthardt@vetmeduni.ac.at |
Keywords: | multiple sclerosis;innate lymphoid cells (ILCs);natural killer cells;experimental autoimmune encephalomyelitis (EAE);autoimmune disease;disease-modifying therapies (DMTs) | Document URI: | http://hdl.handle.net/1942/37816 | ISSN: | 1664-3224 | e-ISSN: | 1664-3224 | DOI: | 10.3389/fimmu.2022.909275 | ISI #: | 000820021800001 | Rights: | 2022 Sadeghi Hassanabadi, Broux, Marinovićand Gotthardt. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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Innate Lymphoid Cells - Neglected Players in Multiple Sclerosis.pdf | Published version | 1.11 MB | Adobe PDF | View/Open |
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