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Title: | Prevention of sudden death in heart failure with reduced ejection fraction: do we still need an implantable cardioverter-defibrillator for primary prevention? | Authors: | Abdelhamid, Magdy Rosano, Giuseppe Metra, Marco Adamopoulos, Stamatis Boehm, Michael Chioncel, Ovidiu Filippatos, Gerasimos Jankowska, Ewa A. Lopatin, Yury Lund, Lars Milicic, Davor Moura, Brenda Ben Gal, Tuvia Ristic, Arsen Rakisheva, Amina Savarese, Gianluigi MULLENS, Wilfried Piepoli, Massimo Bayes-Genis, Antoni Thum, Thomas Anker, Stefan D. Seferovic, Petar Coats, Andrew J. S. |
Issue Date: | 2022 | Publisher: | WILEY | Source: | European journal of heart failure, 24 (9) , p. 1460-1466 | Abstract: | Sudden death is a devastating complication of heart failure (HF). Current guidelines recommend an implantable cardioverter-defibrillator (ICD) for prevention of sudden death in patients with HF and reduced ejection fraction (HFrEF) specifically those with a left ventricular ejection fraction <= 35% after at least 3 months of optimized HF treatment. The benefit of ICD in patients with symptomatic HFrEF caused by coronary artery disease has been well documented; however, the evidence for a benefit of prophylactic ICD implantation in patients with HFrEF of non-ischaemic aetiology is less strong. Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, beta-blockers (BB), and mineralocorticoid receptor antagonists (MRA) block the deleterious actions of angiotensin II, norepinephrine, and aldosterone, respectively. Neprilysin inhibition potentiates the actions of endogenous natriuretic peptides that mitigate adverse ventricular remodelling. BB, MRA, angiotensin receptor-neprilysin inhibitor (ARNI) have a favourable effect on reduction of sudden cardiac death in HFrEF. Recent data suggest a beneficial effect of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in reducing serious ventricular arrhythmias and sudden cardiac death in patients with HFrEF. So, in the current era of new drugs for HFrEF and with the optimal use of disease-modifying therapies (BB, MRA, ARNI and SGLT2i), we might need to reconsider the need and timing for use of ICD as primary prevention of sudden death, especially in HF of non-ischaemic aetiology. | Notes: | Abdelhamid, M (corresponding author), Cairo Univ, Fac Med, Cardiol Dept, Le Rois Villa 29, Cairo 11835, Egypt. magdyabdelhamid@hotmail.com |
Keywords: | Heart failure with reduced ejection fraction;Implantable cardioverter-defibrillator;Sudden death | Document URI: | http://hdl.handle.net/1942/37892 | ISSN: | 1388-9842 | e-ISSN: | 1879-0844 | DOI: | 10.1002/ejhf.2594 | ISI #: | 000826090600001 | Rights: | 2022 European Society of Cardiology | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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