Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/37937
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dc.contributor.authorGevaert, Andreas-
dc.contributor.authorWood, Nathanael-
dc.contributor.authorBoen, Jente-
dc.contributor.authorDavos, Constantinos-
dc.contributor.authorHANSEN, Dominique-
dc.contributor.authorHANSSEN, Ine-
dc.contributor.authorKrenning, Guido-
dc.contributor.authorMoholdt, Trine-
dc.contributor.authorOsto, Elena-
dc.contributor.authorPaneni, Francesco-
dc.contributor.authorPedretti, Roberto-
dc.contributor.authorPlösch, Torsten-
dc.contributor.authorSimonenko, Maria-
dc.contributor.authorBowen, T-
dc.date.accessioned2022-08-29T14:18:24Z-
dc.date.available2022-08-29T14:18:24Z-
dc.date.issued2022-
dc.date.submitted2022-08-27T15:35:51Z-
dc.identifier.citationEuropean journal of preventive cardiology (Print), 29 (17), p.2183-2199-
dc.identifier.issn2047-4873-
dc.identifier.urihttp://hdl.handle.net/1942/37937-
dc.description.abstractIncreasing evidence links changes in epigenetic systems, such as DNA methylation, histone modification, and non-coding RNA expression, to the occurrence of cardiovascular disease (CVD). These epigenetic modifications can change genetic function under influence of exogenous stimuli and can be transferred to next generations, providing a potential mechanism for inheritance of behavioural intervention effects. The benefits of exercise and nutritional interventions in the primary and secondary prevention of CVD are well established, but the mechanisms are not completely understood. In this review, we describe the acute and chronic epigenetic effects of physical activity and dietary changes. We propose exercise and nutrition as potential triggers of epigenetic signals, promoting the reshaping of transcriptional programmes with effects on CVD phenotypes. Finally, we highlight recent developments in epigenetic therapeutics with implications for primary and secondary CVD prevention.-
dc.description.sponsorshipThis work was supported by the Swiss National Science Foundation (Grant PRIMA 24 PR00P3_179861 to EO and grant number 310030_197557 to FP); Swiss Heart Foundation (to EO, and grant numbers FF21076 and FF20045 to FP). TSB was supported by the Medical Research Council (MRC) UK (MR/S025472/1) We thank the late Dr Romualdo Belardinelli for stimulating ideas related to the role of epigenetics in CVD prevention [125] . Parts of Figure 1 and Figure 2 by Servier Medical Art (http://smart.servier.com), licensed under CC-BY-3.0 unported license.-
dc.language.isoen-
dc.publisherOXFORD UNIV PRESS-
dc.rightsThe Author(s) 2022. Published by Oxford University Press on behalf of European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.-
dc.subject.otherDNA methylation-
dc.subject.otherHistone modification-
dc.subject.otherNon-coding RNA-
dc.subject.otherEpigenetic editing-
dc.subject.otherRNA therapeutics-
dc.subject.otherHeart failure-
dc.subject.otherCoronary artery disease-
dc.subject.otherHypertension-
dc.subject.otherPhysical activity-
dc.titleEpigenetics in the primary and secondary prevention of cardiovascular disease: influence of exercise and nutrition 2 3-
dc.typeJournal Contribution-
dc.identifier.epage2199-
dc.identifier.issue17-
dc.identifier.spage2183-
dc.identifier.volume29-
local.bibliographicCitation.jcatA1-
local.publisher.placeGREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.identifier.doi10.1093/eurjpc/zwac179/6672951-
dc.identifier.isi000847371500001-
local.provider.typePdf-
local.uhasselt.internationalyes-
item.fullcitationGevaert, Andreas; Wood, Nathanael; Boen, Jente; Davos, Constantinos; HANSEN, Dominique; HANSSEN, Ine; Krenning, Guido; Moholdt, Trine; Osto, Elena; Paneni, Francesco; Pedretti, Roberto; Plösch, Torsten; Simonenko, Maria & Bowen, T (2022) Epigenetics in the primary and secondary prevention of cardiovascular disease: influence of exercise and nutrition 2 3. In: European journal of preventive cardiology (Print), 29 (17), p.2183-2199.-
item.validationecoom 2023-
item.contributorGevaert, Andreas-
item.contributorWood, Nathanael-
item.contributorBoen, Jente-
item.contributorDavos, Constantinos-
item.contributorHANSEN, Dominique-
item.contributorHANSSEN, Ine-
item.contributorKrenning, Guido-
item.contributorMoholdt, Trine-
item.contributorOsto, Elena-
item.contributorPaneni, Francesco-
item.contributorPedretti, Roberto-
item.contributorPlösch, Torsten-
item.contributorSimonenko, Maria-
item.contributorBowen, T-
item.fulltextWith Fulltext-
item.accessRightsOpen Access-
crisitem.journal.issn2047-4873-
crisitem.journal.eissn2047-4881-
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