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Title: | Epigenetics in the primary and secondary prevention of cardiovascular disease: influence of exercise and nutrition 2 3 | Authors: | Gevaert, Andreas Wood, Nathanael Boen, Jente Davos, Constantinos HANSEN, Dominique HANSSEN, Ine Krenning, Guido Moholdt, Trine Osto, Elena Paneni, Francesco Pedretti, Roberto Plösch, Torsten Simonenko, Maria Bowen, T |
Issue Date: | 2022 | Publisher: | OXFORD UNIV PRESS | Source: | European journal of preventive cardiology (Print), 29 (17), p.2183-2199 | Abstract: | Increasing evidence links changes in epigenetic systems, such as DNA methylation, histone modification, and non-coding RNA expression, to the occurrence of cardiovascular disease (CVD). These epigenetic modifications can change genetic function under influence of exogenous stimuli and can be transferred to next generations, providing a potential mechanism for inheritance of behavioural intervention effects. The benefits of exercise and nutritional interventions in the primary and secondary prevention of CVD are well established, but the mechanisms are not completely understood. In this review, we describe the acute and chronic epigenetic effects of physical activity and dietary changes. We propose exercise and nutrition as potential triggers of epigenetic signals, promoting the reshaping of transcriptional programmes with effects on CVD phenotypes. Finally, we highlight recent developments in epigenetic therapeutics with implications for primary and secondary CVD prevention. | Keywords: | DNA methylation;Histone modification;Non-coding RNA;Epigenetic editing;RNA therapeutics;Heart failure;Coronary artery disease;Hypertension;Physical activity | Document URI: | http://hdl.handle.net/1942/37937 | ISSN: | 2047-4873 | e-ISSN: | 2047-4881 | DOI: | 10.1093/eurjpc/zwac179/6672951 | ISI #: | 000847371500001 | Rights: | The Author(s) 2022. Published by Oxford University Press on behalf of European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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Gevaert et al epigenetics EJPC 2022.pdf | Published version | 1.49 MB | Adobe PDF | View/Open |
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