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Title: | Continuous Crystallization Using Ultrasound Assisted Nucleation, Cubic Cooling Profiles and Oscillatory Flow | Authors: | VANCLEEF, Arne De Beuckeleer , Ward Van Gerven , Tom THOMASSEN, Leen BRAEKEN, Leen |
Issue Date: | 2021 | Publisher: | MDPI | Source: | Processes, 9 (12) (Art N° 2268) | Abstract: | Continuous tubular crystallizers have the potential to reduce manufacturing costs and increase product quality. However, designing tubular crystallizers is a complex and challenging task as crystallization is a complex, multiphase process with a propensity for fouling and clogging. While several designs have been proposed to overcome these issues, these designs are either unproven or poorly scalable and complex. In this work a continuous crystallizer is designed and evaluated to mitigate these issues. The tubular crystallizer combines a novel method to obtain a cubic cooling profile to control the supersaturation, ultrasound to induce nucleation and oscillatory flow to improve mixing and minimize fouling and sedimentation. The results show that the crystallizer was able to operate for more than 4 h without clogging, with high yields and a narrow particle size distribution. The design proposed here is therefore considered a viable approach for continuous crystallizers. | Notes: | Vancleef, A; Braeken, L (corresponding author), Katholieke Univ Leuven, Dept Chem Engn, Res Unit CIPT, Diepenbeek Campus,Agoralaan Gebouw B, B-3590 Diepenbeek, Belgium. arne.vancleef@kuleuven.be; ward.de.beuckeleer@hotmail.be; tom.vangerven@kuleuven.be; leen.thomassen@kuleuven.be; leen.braeken@kuleuven.be |
Keywords: | continuous crystallization;tubular crystallizer;oscillatory baffleless coil reactors;pulsation;oscillatory flow;cubic cooling profile;ultrasound assisted nucleation;fouling | Document URI: | http://hdl.handle.net/1942/38002 | e-ISSN: | 2227-9717 | DOI: | 10.3390/pr9122268 | ISI #: | 000827228200001 | Rights: | 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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Continuous Crystallization Using Ultrasound Assisted Nucleation, Cubic Cooling Profiles and Oscillatory Flow.pdf | Published version | 4.44 MB | Adobe PDF | View/Open |
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