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Title: | SARS-CoV-2 mRNA vaccination is not associated with the induction of anti-HLA or non-HLA antibodies | Authors: | Wijtvliet, Veerle P. W. M. Verheyden, Sonja Depreter, Barbara Heylen, Christine Coeman, Elke ABRAMS, Steven De Winter, Benedicte Y. Massart, Annick Hellemans , Rachel Pipeleers, Lissa Claas, Frans H. J. Arien, Kevin K. Wissing, Karl Martin Abramowicz, Daniel Ledeganck, Kristien J. |
Issue Date: | 2022 | Publisher: | ELSEVIER | Source: | TRANSPLANT IMMUNOLOGY, 74 (Art N° 101670) | Abstract: | Background: SARS-CoV-2 vaccination is strongly recommended in kidney transplant recipients (KTR) and dialysis patients. Whether these vaccinations may trigger alloantibodies, is still debated. Methods: In the current study we evaluated the effect of SARS-CoV-2 mRNA vaccines on anti-Human Leukocyte Antigen (HLA) and 60 anti-non-HLA antibody profiles in clinically stable KTR and dialysis patients. In total, we included 28 KTR, 30 patients on haemodialysis, 25 patients on peritoneal dialysis and 31 controls with a positive seroresponse 16-21 days after the first dose of either the SARS-CoV-2 mRNA BNT162b2 or mRNA-1273 vaccine. Both anti-HLA and anti-non-HLA antibodies were determined prior to vaccination and 21 to 35 days after the second vaccine dose. Results: Overall, the proportion of patients with detectable anti-HLA antibodies was similar before and after vaccination (class I 14% vs. 16%, p = 0.48; class II 25% before and after vaccination). After vaccination, there was no pattern in 1) additionally detected anti-HLA antibodies, or 2) the levels of pre-existing ones. Additional anti-non-HLA antibodies were detected in 30% of the patients, ranging from 1 to 5 new anti-non-HLA antibodies per patient. However, the clinical significance of anti-non-HLA antibodies is still a matter of debate. To date, only a significant association has been found for anti-non-HLA ARHGDIB antibodies and long-term kidney graft loss. No additionally developed anti-ARHGDIB antibodies or elevated level of existing anti-ARHGDIB antibodies was observed. Conclusion: The current data indicate that SARS-CoV-2 mRNA vaccination does not induce anti-HLA or anti-non-HLA antibodies, corroborating the importance of vaccinating KTR and dialysis patients. | Notes: | Wijtvliet, VPWM (corresponding author), Antwerp Univ Hosp, Dept Nephrol & Hypertens, Drie Eikenstr 655, B-2650 Edegem, Belgium. veerle.wijtvliet@uantwerpen.be |
Keywords: | Antibodies;Human leukocyte antigen (HLA);Minor antigen;SARS-CoV-2;Vaccination | Document URI: | http://hdl.handle.net/1942/38029 | ISSN: | 0966-3274 | e-ISSN: | 1878-5492 | DOI: | 10.1016/j.trim.2022.101670 | ISI #: | 000835335500014 | Rights: | 2022 Elsevier B.V. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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