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Title: | Skeletal Muscles of Patients Infected with SARS-CoV-2 Develop Severe Myofiber Damage upon One Week of Admission on the Intensive Care Unit | Authors: | STEVENS, Sjoerd Hendrickx, Paul Snijders, Tim LAMBRICHTS, Ivo STESSEL, Bjorn Dubois, Jasperina van Loon, Luc J. C. VANDENABEELE, Frank AGTEN, Anouk |
Issue Date: | 2022 | Publisher: | MDPI | Source: | Applied sciences (Basel), 12 (14) (Art N° 7310) | Abstract: | Many critically ill patients infected with SARS-CoV-2 have been submitted to an intensive care unit (ICU). Patients with a SARS-CoV-2 infection that survive critical illness are confronted with months of physical impairments. To maximize recovery, it is important to understand the musculoskeletal involvement in critically ill patients infected with SARS-CoV-2. The aim of the present study was to assess the myocellular changes in SARS-CoV-2 patients that occur throughout the first week of ICU admission. In n = 22 critically ill patients infected with SARS-CoV-2, a biopsy sample from the vastus lateralis muscle was obtained at day 1-3 and day 5-8 following ICU admission. Fluorescence microscopy was used to assess type I and type II muscle fiber size and distribution, myonuclear content, and muscle tissue capillarization. Transmission electron microscopy was used to support quantitative data at an ultrastructural level. Changes in type I and type II muscle fiber size showed large inter-individual variation. The average change in type I fiber size was +309 +/- 1834 mu m(2), ranging from -2129 mu m(2) (-31%) to +3375 mu m(2) (+73%). The average change in type II fiber size was -224 +/- 1256 mu m(2), ranging from -1410 mu m(2) (-36%) to +2592 mu m(2) (+48%). Ultrastructural observations showed myofibrillar and hydropic degeneration, and fiber necrosis. This study shows that ICU patients admitted with SARS-CoV-2 suffer from substantial muscle fiber damage during ICU admission. These results are a call for action towards more specialized rehabilitation programs for patients admitted to the ICU with SARS-CoV-2 infection. | Notes: | Vandenabeele, F; Agten, A (corresponding author), Hasselt Univ, Fac Rehabil Sci & Physiotherapy, Rehabil Res Ctr, B-3590 Diepenbeek, Belgium.; Agten, A (corresponding author), Maastricht Univ, Fac Hlth Med & Life Sci, Dept Human Anat & Embryol, NL-6229 ER Maastricht, Netherlands. sjoerd.stevens@uhasselt.be; paul.hendrickx@student.kuleuven.be; tim.snijders@maastrichtuniversity.nl; ivo.lambrichts@uhasselt.be; bjorn.stessel@jessazh.be; jasperina.dubois@jessazh.be; l.vanloon@maastrichtuniversity.nl; frank.vandenabeele@uhasselt.be; anouk.agten@uhasselt.be |
Keywords: | severe acute respiratory syndrome virus;skeletal muscles;sepsis;respiratory distress syndrome;critical illness | Document URI: | http://hdl.handle.net/1942/38043 | e-ISSN: | 2076-3417 | DOI: | 10.3390/app12147310 | ISI #: | 000831921700001 | Rights: | 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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Skeletal Muscles of Patients Infected with SARS-CoV-2 Develop Severe Myofiber Damage upon One Week of Admission on the Intensive Care Unit.pdf | Published version | 8.33 MB | Adobe PDF | View/Open |
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