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Title: | Cascade of care among hepatitis B patients in Maastricht, the Netherlands, 1996 to 2018 | Authors: | van Oorschot, Eva KOC, Ozgur Lashof, Astrid Ml Oude van Loo, Inge Hm Ackens, Robin Posthouwer, Dirk Koek, Ger H. |
Issue Date: | 2022 | Publisher: | MEDISCRIPT LTD | Source: | Journal of Virus Eradication, 8 (2) | Abstract: | Background & aims: There are approximately 49,000 people (0.34%) in the Netherlands with a chronic hepatitis B virus (HBV) infection. It is unclear how many are linked to care and under follow-up in hepatitis outpatient clinics. This study determined the cascade of care and identified predictors for not being linked to care and loss to follow-up in Maastricht, the Netherlands. Methods: All hepatitis B surface antigen (HBsAg)-positive patients between December 1, 1996 and September 30, 2018 were retrospectively identified. Results: In total, 644 HBsAg-positive patients were identified; of whom 75 had acute HBV infection, 471 chronic HBV infection and 98 unknown. Out of 569 individuals with a chronic/unknown HBV status, 134/569 (23.6%) were not linked to care and 58.7% (195/332 after excluding those who died or achieved HBsAg-seroclearance) were loss to follow-up (LTFU). A predictor for not being linked to care was Caucasian ethnicity (odds ratio (OR) = 2.76 (95% Confidence Interval (CI) = 1.21-6.29); p =.015). Predictors for LTFU were older age (OR = 0.97 (CI = 0.94-0.99); p =.008), HBV DNA >20,000 IU/mL (OR = 0.44 (CI = 0.21 - 0.93); p =.033) and Asian ethnicity (OR = 0.46, (CI = 0.21-1.00); p =.050). Rates of not being linked to care and LTFU decreased over time from 12.7% in 1996 to 4.4% in 2018 and from 79.2% in 1996 to 37.2% in 2018, respectively. Conclusions: A considerable amount of HBsAg-positive individuals were not linked to care or LTFU. This study indicates that ethnicity plays a role in linkage to care and follow-up. Further research is needed to elaborate on those results. | Notes: | van Oorschot, E (corresponding author), Maastricht UMC, P Debyelaan 25, NL-6229 HX Maastricht, Netherlands. eva.van.oorschot@mumc.nl; o.kuc@mumc.nl; a.oudelashof@mumc.nl; ihm.van.loo@mumc.nl; r.sckens@mumc.nl; d.posthouwer@mumc.nl; gh.koek@mumc.nl |
Keywords: | Hepatitis B;Cascade of care;Linkage to care;Loss to follow-up;Ethnicity The Netherlands | Document URI: | http://hdl.handle.net/1942/38086 | ISSN: | 2055-6640 | e-ISSN: | 2055-6659 | DOI: | 10.1016/j.jve.2022.100075 | ISI #: | 000836448600005 | Rights: | 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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