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http://hdl.handle.net/1942/3821
Title: | Immune disturbances during major depression - Up-regulated expression of interleukin-2 receptors | Authors: | Maes, Michael BOSMANS, E SUY, E DEJONCKHEERE, C VANDERVORST, Carine RAUS, Jef |
Issue Date: | 1991 | Publisher: | KARGER | Source: | NEUROPSYCHOBIOLOGY, 24(3). p. 115-120 | Abstract: | We determined the following immune parameters in drug-free, major depressed patients and in age- and sex-matched healthy controls: the number and percentage of interleukin-2 receptor (IL-2R) bearing cells (CD25+, anti-TAC), serum circulating levels of soluble (s)IL-2Rs, the pre- and postdexamethasone phytohemagglutinin (PHA)-induced accumulation of sIL-2Rs in culture supernatant, and the number of T helper (CD4+) and T suppressor (CD8+) cells. In comparison with normal volunteers, patients with major depression had a higher number and percentage of CD25+ cells, higher concentrations of serum circulating sIL-2Rs, higher supernatant sIL-2Rs after stimulation with PHA, and a higher number of CD4+ cells. The CD4+/CD8+ ratio and the number of CD4+ cells were significantly and positively related to the number of cells expressing the CD25+ antigen. These results may indicate that depressed patients display an increased number of T cells in an early phase of activation. | Notes: | DR WILLEMS INST,DIEPENBEEK,BELGIUM. EUROGENET,TESSENDERLOO,BELGIUM.MAES, M, PSYCHIAT CTR ST JOSEF,ABDIJST 2,B-3751 MUNSTERBILZEN,BELGIUM. | Keywords: | DEPRESSION; INTERLEUKIN-2; SOLUBLE INTERLEUKIN-2 RECEPTORS; ACTIVATED T-CELLS; FLOW CYTOMETRY | Document URI: | http://hdl.handle.net/1942/3821 | ISI #: | A1991HG89000003 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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