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http://hdl.handle.net/1942/3827
Title: | HPA-axis hormones and prolactin responses to dextro-fenfluramine in depressed-patients and healthy controls | Authors: | Maes, Michael DHONDT, P SUY, E MINNER, B VANDERVORST, Carine RAUS, Jef |
Issue Date: | 1991 | Publisher: | PERGAMON-ELSEVIER SCIENCE LTD | Source: | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 15(6). p. 781-790 | Abstract: | 1. Like other authors we have established disturbances in central serotonergic neurotransmission in severely depressed patients by implementing hypothalamic pituitary adrenal (HPA)-axis hormones and prolactin responses to serotonin agonists or precursors. 2. Challenge probes with D,L fenfluramine have yielded controversial results. This substance, however, is not as serotonin-selective as previously believed. 3. Dextro(D)-fenfluramine, the dextrorotatory isomer of fenfluramine, constitutes a specific and potent serotonergic agonist. 4. In the present study the authors determined the following in healthy volunteers, and in depressed inpatients: the adrenocorticotropic hormone (ACTH), beta-endorphin, prolactin and cortisol responses to D-fenfluramine administration (45 mg orally), total L-tryptophan and the 8 a.m. postdexamethasone cortisol values. 5. We found no significant differences in any of the post-D-fenfluramine hormone levels across healthy controls, minor, simple major and melancholic depressives. There were no significant correlations between L-tryptophan or postdexamethasone cortisol on the one hand, and any of the post-D-fenfluramine hormone values on the other. | Notes: | PSYCHIAT CTR ST JOSEF,MUNSTERBILZEN,BELGIUM. UNIV DIEPENBEEK,DR WILLEMS INST,DIEPENBEEK,BELGIUM. | Keywords: | DEPRESSION; DEXAMETHASONE SUPPRESSION TEST; D-FENFLURAMINE; SEROTONERGIC PROBES; TRYPTOPHAN | Document URI: | http://hdl.handle.net/1942/3827 | DOI: | 10.1016/0278-5846(91)90007-N | ISI #: | A1991GN29700007 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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