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Title: | Veno-venous extra-corporeal membrane oxygenation in a COVID-19 patient with cold-agglutinin haemolytic anaemia: A case report | Authors: | Raes, Matthias De Becker, Ann Blanckaert, Jeroen Balthazar, Tim De Ridder , Simon Mekeirele, Michael VERBRUGGE, Frederik Poelaert, Jan Taccone, Fabio Silvio |
Issue Date: | 2022 | Publisher: | SAGE PUBLICATIONS LTD | Source: | PERFUSION-UK, 38 (8) , p.1746-1750 | Abstract: | Overview The use of extra-corporeal membrane oxygenation (ECMO) therapy to treat severe COVID-19 patients with acute respiratory failure is increasing worldwide. We reported herein the use of veno-venous ECMO in a patient with cold agglutinin haemolytic anaemia (CAHA) who suffered from severe COVID-19 infection. Description A 64-year-old man presented to the emergency department (ED) with incremental complaints of dyspnoea and cough since one week. His history consisted of CAHA, which responded well to corticosteroid treatment. Because of severe hypoxemia, urgent intubation and mechanical ventilation were necessary. Despite deep sedation, muscle paralysis and prone ventilation, P/F ratio remained low. Though his history of CAHA, he still was considered for VV-ECMO. As lab results pointed to recurrence of CAHA, corticosteroids and rituximab were started. The VV-ECMO run was short and rather uncomplicated. Although, despite treatment, CAHA persisted and caused important complications of intestinal ischemia, which needed multiple surgical interventions. Finally, the patient suffered from progressive liver failure, thought to be secondary to ischemic cholangitis. One month after admission, therapy was stopped and patient passed away. Conclusion Our case report shows that CAHA is no contraindication for VV-ECMO, even when both titre and thermal amplitude are high. Although, the aetiology of CAHA and its response to therapy will determine the final outcome of those patients. | Notes: | Raes, M (corresponding author), Dept Intens Care, Laarbeeklaan 101, B-1090 Brussels, Belgium. matthias.raes@uzbrussel.be |
Keywords: | Venovenous;extra-corporeal membrane oxygenation;cold agglutinins;case report;haemolytic anaemia;COVID-19 | Document URI: | http://hdl.handle.net/1942/38730 | ISSN: | 0267-6591 | e-ISSN: | 1477-111X | DOI: | 10.1177/02676591221127932 | ISI #: | 000858541100001 | Rights: | The Author(s) 2022 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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