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Title: | Perinatal outcome of babies born after using a simplified IVF culture system versus ICSI with sibling oocytes: a prospective cohort study | Authors: | OMBELET, Willem Van Blerkom, Jonathan NARGUND, Geeta Janssen, Mia Jacobs, Petra Auwera, Ingrid Van der Dhont, Nathalie Bosmans, Eugene Vertessen, Viktor-Jan Campo, Rudi |
Issue Date: | 2022 | Publisher: | ELSEVIER SCI LTD | Source: | REPRODUCTIVE BIOMEDICINE ONLINE, 45 (3) , p. 574 -582 | Abstract: | Research question: Is there a difference in perinatal outcome in the same patient cohort for babies conceived following randomization of sibling oocytes allocated to a simplified IVF culture system (SCS) or intracytoplasmic sperm injection (ICSI) followed by conventional culturing? Design: The study compared the perinatal outcomes of 367 babies born from 1 January 2013 until 31 December 2020 after using split SCS and ICSI insemination of sibling oocytes in a selected group of normo-responsive women, excluding cases of severe male infertility. Primary outcome measures were preterm birth (PTB; <37 weeks' gestation), low birthweight (LBW; <2.5 kg) and small for gestational age (SGA) as a primary outcome parameter while secondary outcome measures included mean birthweight, mean gestational age, extreme prematurity (<32 weeks), very low birthweight (<1.5 kg), perinatal mortality, multiple pregnancy and Caesarean section rate. Results: A total of 105 and 103 singleton babies were born after fresh embryo transfer (FRET) and 71 and 50 singletons after frozen embryo transfer (FET) in the SCS and ICSI groups, respectively. For babies born after FRET, the LBW rate was 2.9% (3/105) for SCS and 78% (8/103) for ICSI (P = 0.10). LBW occurred in 4.2% (3/71) and 0% (0/50) of babies born after the transfer of cryopreserved-thawed SCS and ICSI embryos, respectively (P = 0.14). The rate of PTB was 3.8% and 6.8% for SCS and ICSI in FRET cycles (P = 0.33), and 8.5% and 6.0% for SCS and ICSI in FET cycles (P = 0.62). One congenital malformation was found in the SCS FET group. Conclusion: There was no difference in perinatal outcome for singleton and twin babies born after SCS and ICSI. | Notes: | Ombelet, W (corresponding author), ZOL, Genk Inst Fertil Technol, Dept Obstet & Gynaecol, Campus St Jan, Genk, Belgium.; Ombelet, W (corresponding author), Hasselt Univ, Fac Med & Life Sci, Agoralaan, Diepenbeek, Belgium. willem.ombelet@telenet.be |
Keywords: | Assisted reproduction;Intracytoplasmic sperm injection (ICSI);Low birthweight;Perinatal outcome;Prematurity;Simplified IVF | Document URI: | http://hdl.handle.net/1942/38798 | ISSN: | 1472-6483 | e-ISSN: | 1472-6491 | DOI: | 10.1016/j.rbmo.2022.04.009 | ISI #: | 000862853900015 | Rights: | 2022 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. *Corresponding author. E-mail address: willem.ombelet@telenet.be (W. Ombelet). https://doi.org/10.1016/j. rbmo.2022.04.009 1472-6483/© 2022 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. Declaration: The authors report no financial or commercial conflicts of interest. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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