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Title: | The impact of brain lesion characteristics and the corticospinal tract wiring on mirror movements in unilateral cerebral palsy | Authors: | Simon-Martinez, Cristina DECRAENE, Lisa Zielinski, Ingar Hoare, Brian Williams, Jacqueline Mailleux, Lisa Steenbergen, Bert Ortibus, Els Feys, Hilde KLINGELS, Katrijn |
Issue Date: | 2022 | Publisher: | NATURE PORTFOLIO | Source: | Scientific Reports, 12 (1) (Art N° 16301) | Abstract: | Mirror movements (MM) influence bimanual performance in children with unilateral cerebral palsy (uCP). Whilst MM are related to brain lesion characteristics and the corticospinal tract (CST) wiring pattern, the combined impact of these neurological factors remains unknown. Forty-nine children with uCP (mean age 10y6mo) performed a repetitive squeezing task to quantify similarity (MM-similarity) and strength (MM-intensity) of the MM activity. We used MRI data to evaluate lesion type (periventricular white matter, N = 30; cortico-subcortical, N = 19), extent of ipsilesional damage, presence of bilateral lesions, and damage to basal ganglia, thalamus and corpus callosum. The CST wiring was assessed with Transcranial Magnetic Stimulation (17 CSTcontralateral, 16 CSTipsilateral, 16 CSTbilateral). Data was analyzed with regression analyses. In the more-affected hand, MM-similarity and intensity were higher with CSTbilateral/ipsilateral. In the less-affected hand, MM-similarity was higher in children with (1) CSTcontra with CSC lesions, (2) CSTbilat/ipsi with PVL lesions and (3) CSTbilat/ipsi with unilateralized lesions. MM-intensity was higher with larger damage to the corpus callosum and unilateral lesions. A complex combination of neurological factors influences MM characteristics, and the mechanisms differ between hands. | Notes: | Simon-Martinez, C (corresponding author), Univ Leuven, KU Leuven, Dept Rehabil Sci, Leuven, Belgium.; Simon-Martinez, C (corresponding author), Univ Appl Sci Western Switzerland HES SO, Inst Informat Syst, Rue Techno Pole 3, CH-3960 Sierre, Switzerland.; Simon-Martinez, C (corresponding author), Univ Bern, Bern Univ Hosp, Univ Childrens Hosp, Div Neuropediat Dev & Rehabil,Inselspital, Bern, Switzerland. cristina.simon@hevs.ch |
Document URI: | http://hdl.handle.net/1942/38825 | ISSN: | 2045-2322 | e-ISSN: | 2045-2322 | DOI: | 10.1038/s41598-022-19920-z | ISI #: | 000862059200015 | Rights: | Te Author(s) 2022. Open Access Tis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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The impact of brain lesion characteristics and the corticospinal tract wiring on mirror movements in unilateral cerebral palsy.pdf | Published version | 1.39 MB | Adobe PDF | View/Open |
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