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Title: | Addressing transcranial electrical stimulation variability through prospective individualized dosing of electric field strength in 300 participants across two samples: the 2-SPED approach | Authors: | VAN HOORNWEDER, Sybren Caulfield, Kevin A. Nitsche, Michael Thielscher, Axel MEESEN, Raf |
Issue Date: | 2022 | Publisher: | IOP Publishing Ltd | Source: | Journal of Neural Engineering, 19 (5) (Art N° 056045) | Abstract: | Objective. Transcranial electrical stimulation (tES) is a promising method for modulating brain activity and excitability with variable results to date. To minimize electric (E-)field strength variability, we introduce the 2-sample prospective E-field dosing (2-SPED) approach, which uses E-field strengths induced by tES in a first population to individualize stimulation intensity in a second population. Approach. We performed E-field modeling of three common tES montages in 300 healthy younger adults. First, permutation analyses identified the sample size required to obtain a stable group average E-field in the primary motor cortex (M1), with stability being defined as the number of participants where all group-average E-field strengths +/- standard deviation did not leave the population's 5-95 percentile range. Second, this stable group average was used to individualize tES intensity in a second independent population (n = 100). The impact of individualized versus fixed intensity tES on E-field strength variability was analyzed. Main results. In the first population, stable group average E-field strengths (V/m) in M1 were achieved at 74-85 participants, depending on the tES montage. Individualizing the stimulation intensity (mA) in the second population resulted in uniform M1 E-field strength (all p < 0.001) and significantly diminished peak cortical E-field strength variability (all p < 0.01), across all montages. Significance. 2-SPED is a feasible way to prospectively induce more uniform E-field strengths in a region of interest. Future studies might apply 2-SPED to investigate whether decreased E-field strength variability also results in decreased physiological and behavioral variability in response to tES. | Notes: | Van Hoornweder, S (corresponding author), Univ Hasselt, Fac Rehabil Sci, REVAL Rehabil Res Ctr, Diepenbeek, Belgium. Sybren.vanhoornweder@uhasselt.be |
Keywords: | electric field (E-field) modeling;transcranial electrical stimulation (tES);transcranial direct current stimulation (tDCS);finite element method (FEM);noninvasive brain stimulation;computational dosimetry | Document URI: | http://hdl.handle.net/1942/38878 | ISSN: | 1741-2560 | e-ISSN: | 1741-2552 | DOI: | 10.1088/1741-2552/ac9a78 | ISI #: | 000875336600001 | Rights: | 2022 The Author(s). Published by IOP Publishing Ltd. Open access | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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Addressing transcranial electrical stimulation variability through prospective individualized dosing of electric field strength in 300 participants across two samples_ the 2-SPED approach.pdf | Published version | 1.99 MB | Adobe PDF | View/Open |
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