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|Title:||NOVEL ANTIBODY BIOMARKERS THAT PREDICT FAILURE TO ACHIEVE EARLY AND SUSTAINED DISEASE REMISSION OR LOW DISEASE ACTIVITY AFTER INTENSIVE FIRST-LINE THERAPY IN RHEUMATOID ARTHRITIS||Authors:||VANDORMAEL, Patrick
|Issue Date:||2022||Publisher:||BMJ PUBLISHING GROUP||Source:||ANNALS OF THE RHEUMATIC DISEASES, 81 , p. 299||Abstract:||Scientific Abstracts 299 ANOSIM). Detailly, at the genera level, IIM patients had a higher abundance of Ente-rococcus, Veillonella, Streptococcus, et al. and a lower abundance of Roseburia, Lachnospira, Klebsiella, et al(Figure 1D, p < 0.05). In IIM patients, Fusobacteriota correlated positively with the ratio of Th1 cells (Figure 1E, p < 0.01), and there was a significant positive correlation between Synergistota and B lymphocyte (Figure 1E, p < 0.01). Besides, Euryarchaeota and Cyanobacteria were both positively and significantly related to IL-6, IFN-γ and C-reactive protein (CRP) (Figure 1E, p < 0.001). Conclusion: Richness and diversity of intestinal flora in IIM patients were impaired, which might participate in the pathogenesis of IIM by disturbing lym-phocyte subpopulations and cytokines. Regulating intestinal flora and restoring homeostasis might become a critical therapeutic methods of IIM. REFERENCES:  Xu Y, Sun J, Wan K, et al. Multiparametric cardiovascular magnetic resonance characteristics and dynamic changes in myocardial and skeletal muscles in idiopathic inflammatory cardiomyopathy. J Cardiovasc Magn Reson 2020;22(1):22.||Document URI:||http://hdl.handle.net/1942/38888||ISSN:||0003-4967||e-ISSN:||1468-2060||DOI:||10.1136/annrheumdis-2022-eular.2388||ISI #:||000850279001084||Category:||M||Type:||Journal Contribution|
|Appears in Collections:||Research publications|
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