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http://hdl.handle.net/1942/389
Title: | Sexual dysfunction associated with protease inhibitor containing highly active antiretroviral treatment | Authors: | SCHROOTEN, Ward Colebunders, Robert Youle, Mike MOLENBERGHS, Geert Dedes, Nikos Koitz, Gunvor Finazzi, Renato de Mey, Inge Florence, Eric DREEZEN, Christa |
Corporate Authors: | Eurosupport Study Group | Issue Date: | 2001 | Publisher: | LIPPINCOTT WILLIAMS & WILKINS | Source: | AIDS, 15(8). p. 1019-1023 | Abstract: | BACKGROUND: A high proportion of individuals receiving highly active antiretroviral treatment (HAART) complain of sexual dysfunction (SD), encompassing a lack of desire or erectile dysfunction. OBJECTIVE: To determine whether SD was associated with particular components of the HAART regimens and to identify risk factors for the development of SD in patients on HAART. METHODS: A survey among patients with HIV infection using an anonymous questionnaire was conducted in 10 European countries between December 1998 and December 1999. A total of 904 individuals currently receiving antiretroviral agents were included in the analyses. RESULTS: A decrease in sexual interest was significantly more frequently reported by subjects (men and women) using HAART containing protease inhibitors (PI) (308/766, 40%), compared with PI-naive patients (22/138, 16%; OR 3.55; 95% CI 2.15--5.89). In addition, a significantly larger number of PI-experienced men reported a decrease in sexual potency (216/628, 34%) compared with PI-naive men (12/99, 12%; OR 2.56; 95% CI 1.33--5.03). In multivariate analyses the following factors were associated with a decrease in sexual interest: a current PI-containing regimen, a history of a PI regimen, symptomatic HIV infection, age and homosexual contact as HIV transmission mode. Factors associated with a decrease in sexual potency were: current use of a PI-containing regimen, symptomatic HIV disease, age and the use of tranquillisers. CONCLUSION: SD appears to be a common side-effect of HAART regimens containing a PI. The potential association between SD and other side-effects of HAART, such as lipodystrophy syndrome and neuropathy, should be investigated further. | Keywords: | antiretroviral therapy; erection problems; sexual desire | Document URI: | http://hdl.handle.net/1942/389 | ISSN: | 0269-9370 | e-ISSN: | 1473-5571 | DOI: | 10.1097/00002030-200105250-00010 | ISI #: | 000168930100009 | Rights: | (C) 2001 Lippincott Williams & Wilkins | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2002 |
Appears in Collections: | Research publications |
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