Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/39084
Title: | Walking fatigability manifests globally in several gait domains in people with multiple sclerosis during a prolonged walking | Authors: | BALISTIERI SANTINELLI, Felipe RAMARI FERREIRA, Cintia GYSEMBERG, Griet VAN WIJMEERSCH, Bart Kos, D. MEYNS, Pieter FEYS, Peter |
Issue Date: | 2022 | Publisher: | SAGE PUBLICATIONS LTD | Source: | Multiple Sclerosis Journal, 28 (S3) , p. 995 | Abstract: | LB ePoster 28 (3S) 995 journals.sagepub.com/home/msj Multiple Sclerosis Journal 2022; 28: (3S) 984-1017 found with those who were frail. The rate of all-cause mortality was higher in PwMS who were frail without depression (HR 1.34, 95%CI 1.09-1.65), those fit with depression (HR 1.19, 95%CI 1.08-1.32), and those frail with depression (HR 2.02, 95%CI 1.35-3.01). In women, 38% of the mortality outcome was attributable to the joint effect of the two conditions (AP 0.38, 95%CI 0.07-0.68). Conclusions: Depression is associated with increased risk of macrovascular disease and both frailty and depression are associated with increased risk of all-cause mortality. The effect is syn-ergistic in women. Further studies should evaluate whether effectively treating depression and enhanced management of frailty are associated with reduced vascular risk and mortality. Disclosure In the last 3 years, Raffaele Palladino received support from the UK MS Society and had taken part in advisory boards/consul-tancy for Sanofi. | Document URI: | http://hdl.handle.net/1942/39084 | ISSN: | 1352-4585 | e-ISSN: | 1477-0970 | ISI #: | 000866540804015 | Category: | M | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
EP1226.pdf | Published version | 53.87 kB | Adobe PDF | View/Open |
Google ScholarTM
Check
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.