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http://hdl.handle.net/1942/39175
Title: | In Utero Exposure to Air Pollutants and Mitochondrial Heteroplasmy in Neonates | Authors: | COSEMANS, Charlotte WANG, Congrong MARTENS, Dries JANSSEN, Bram Vanpoucke, Charlotte Lefebvre, Wouter SMEETS, Karen NAWROT, Tim PLUSQUIN, Michelle |
Issue Date: | 2022 | Publisher: | AMER CHEMICAL SOC | Source: | ENVIRONMENTAL SCIENCE & TECHNOLOGY, 57 (1), p. 350-359 | Abstract: | Mitochondria are sensitive to oxidative stress, which can be caused by traffic-related air pollution. Placental mitochondrial DNA (mtDNA) mutations have been previously linked with air pollution. However, the relationship between prenatal air pollution and cord-blood mtDNA mutations has been poorly understood. Therefore, we hypothesized that prenatal particulate matter (PM2.5) and NO2 exposures are associated with cord-blood mtDNA heteroplasmy. As part of the ENVIRONAGE cohort, 200 mother-newborn pairs were recruited. Cord-blood mitochondrial single-nucleotide polymorphisms were identified by whole mitochondrial genome sequencing, and heteroplasmy levels were evaluated based on the variant allele frequency (VAF). Outdoor PM2.5 and NO2 concentrations were determined by a high resolution spatial-temporal interpolation method based on the maternal residential address. Distributed lag linear models were used to determine sensitive time windows for the association between NO2 exposure and cord-blood mtDNA heteroplasmy. A 5 mu g/m3 increment in NO2 was linked with MT-D-Loop16311T>C heteroplasmy from gestational weeks 17-25. MT-CYTB14766C>T was negatively associated with NO2 exposure in mid pregnancy, from weeks 14-17, and positively associated in late pregnancy, from weeks 31-36. No significant associations were observed with prenatal PM2.5 exposure. This is the first study to show that prenatal NO2 exposure is associated with cord-blood mitochondrial mutations and suggests two critical windows of exposure in mid-to-late pregnancy. | Notes: | Plusquin, M (corresponding author), Hasselt Univ, Ctr Environm Sci, B-3590 Diepenbeek, Belgium. michelle.plusquin@uhasselt.be |
Keywords: | mitochondria;SNP;heteroplasmy;air pollution;DLM | Document URI: | http://hdl.handle.net/1942/39175 | ISSN: | 0013-936X | e-ISSN: | 1520-5851 | DOI: | 10.1021/acs.est.2c02556 | ISI #: | 000898882600001 | Rights: | XXXX American Chemical Society | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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In Utero Exposure to Air Pollutants and Mitochondrial Heteroplasmy in Neonates.pdf Restricted Access | Published version | 1.75 MB | Adobe PDF | View/Open Request a copy |
In utero exposure.pdf | Peer-reviewed author version | 1.56 MB | Adobe PDF | View/Open |
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