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Title: | Microglia states and nomenclature: A field at its crossroads | Authors: | Paolicelli, Rosa C. Sierra, Amanda Stevens, Beth Tremblay, Marie-Eve Aguzzi, Adriano Ajami, Bahareh Amit, Ido Audinat, Etienne Bechmann, Ingo Bennett, Mariko Bennett, Frederick Bessis, Alain Biber, Knut Bilbo, Staci Blurton-Jones, Mathew Boddeke, Erik Brites, Dora BRONE, Bert Brown, Guy C. Butovsky, Oleg Carson, Monica J. Castellano, Bernardo Colonna, Marco Cowley, Sally A. Cunningham, Colm Davalos, Dimitrios De Jager, Philip L. de Strooper, Bart Denes, Adam Eggen, Bart J. L. Eyo, Ukpong Galea, Elena Garel, Sonia Ginhoux, Florent Glass, Christopher K. Gokce, Ozgun Gomez-Nicola, Diego Gonzalez, Berta Gordon, Siamon Graeber, Manuel B. Greenhalgh, Andrew D. Gressens, Pierre Greter, Melanie Gutmann, David H. Haass, Christian Heneka, Michael T. Heppner, Frank L. Hong, Soyon Hume, David A. Jung, Steffen Kettenmann, Helmut Kipnis, Jonathan Koyama, Ryuta Lemke, Greg Lynch, Marina Majewska, Ania Malcangio, Marzia Malm, Tarja Mancuso, Renzo Masuda, Takahiro Matteoli, Michela McColl, Barry W. Miron, Veronique E. Molofsky, Anna Victoria Monje, Michelle Mracsko, Eva Nadjar, Agnes Neher, Jonas J. Neniskyte, Urte Neumann, Harald Noda, Mami Peng, Bo Peri, Francesca Perry, V. Hugh Popovich, Phillip G. Pridans, Clare Priller, Josef Prinz, Marco Ragozzino, Davide Ransohoff, Richard M. Salter, Michael W. Schaefer, Anne Schafer, Dorothy P. Schwartz, Michal Simons, Mikael Smith, Cody J. Streit, Wolfgang J. Tuan Leng Tay Tsai, Li-Huei Verkhratsky, Alexei von Bernhardi, Rommy Wake, Hiroaki Wittamer, Valerie Wolf, Susanne A. Wu, Long-Jun Wyss-Coray, Tony |
Issue Date: | 2022 | Publisher: | CELL PRESS | Source: | NEURON, 110 (21) , p. 3458 -3483 | Abstract: | Microglial research has advanced considerably in recent decades yet has been constrained by a rolling series of dichotomies such as ``resting versus activated'' and ``M1 versus M2.'' This dualistic classification of good or bad microglia is inconsistent with the wide repertoire of microglial states and functions in development, plasticity, aging, and diseases that were elucidated in recent years. New designations continuously arising in an attempt to describe the different microglial states, notably defined using transcriptomics and proteomics, may easily lead to a misleading, although unintentional, coupling of categories and functions. To address these issues, we assembled a group of multidisciplinary experts to discuss our current understanding of microglial states as a dynamic concept and the importance of addressing microglial function. Here, we provide a conceptual framework and recommendations on the use of microglial nomenclature for researchers, reviewers, and editors, which will serve as the foundations for a future white paper. | Notes: | Paolicelli, RC (corresponding author), Univ Lausanne, Fac Biol & Med, Dept Biomed Sci, Lausanne, Switzerland.; Sierra, A (corresponding author), Achucarro Basque Ctr Neurosci, Glial Cell Biol Lab, Leioa, Spain.; Sierra, A (corresponding author), Univ Basque Country EHU UPV, Dept Neurosci, Leioa, Spain.; Sierra, A (corresponding author), Ikerbasque Fdn, Bilbao, Spain.; Stevens, B (corresponding author), Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.; Stevens, B (corresponding author), Howard Hughes Med Inst, HHMI, Cambridge, MD 02139 USA.; Stevens, B (corresponding author), Boston Childrens Hosp, Boston, MA 02115 USA.; Tremblay, ME (corresponding author), Univ Laval, CHU Quebec, Ctr Rech, Quebec City, PQ, Canada.; Tremblay, ME (corresponding author), McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ, Canada.; Tremblay, ME (corresponding author), Univ Victoria, Div Med Sci, Victoria, BC, Canada.; Tremblay, ME (corresponding author), Univ Victoria, Ctr Adv Mat & Related Technol CAMTEC, Victoria, BC, Canada.; Tremblay, ME (corresponding author), Univ British Columbia, Dept Biochem & Mol Biol, Vancouver, BC, Canada. rosachiara.paolicelli@unil.ch; amanda.sierra@ehu.eus; beth.stevens@childrens.harvard.edu; evetremblay@uvic.ca |
Keywords: | Microglia | Document URI: | http://hdl.handle.net/1942/39540 | ISSN: | 0896-6273 | e-ISSN: | 1097-4199 | DOI: | doi.org/10.1016/j.neuron.2022.10.020 | ISI #: | 000915789000010 | Rights: | 2022 Elsevier Inc. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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Microglia states and nomenclature_ A field at its crossroads.pdf Restricted Access | Published version | 2.79 MB | Adobe PDF | View/Open Request a copy |
Manuscipt_Final.pdf | Non Peer-reviewed author version | 496.75 kB | Adobe PDF | View/Open |
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