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http://hdl.handle.net/1942/39546| Title: | The energy-splicing resilience axis hypothesis of aging | Authors: | Ferrucci, Luigi WILSON, David Donega, Stefano Gorospe, Myriam |
Issue Date: | 2022 | Publisher: | SPRINGERNATURE | Source: | Nature aging, 2 (3) , p. 182 -185 | Abstract: | Aging can be conceptualized as the stochastic accumulation of damage and loss of resilience leading to organism demise. Resilience mechanisms that repair, recycle or replace damaged molecules and organelles are energy-demanding, therefore energy availability is essential to healthy aging. We propose that changes in mitochondrial and energy status regulate RNA splicing and that splicing is a resilience strategy that preserves energetic homeostasis with aging. | Notes: | Ferrucci, L (corresponding author), NIA, Biomed Res Ctr, NIH, Baltimore, MD 21224 USA. ferruccilu@grc.nia.nih.gov |
Document URI: | http://hdl.handle.net/1942/39546 | e-ISSN: | 2662-8465 | DOI: | 10.1038/s43587-022-00189-w | ISI #: | 000916575600002 | Category: | A2 | Type: | Journal Contribution |
| Appears in Collections: | Research publications |
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| The energy–splicing resilience axis hypothesis of aging.pdf Restricted Access | Published version | 904.73 kB | Adobe PDF | View/Open Request a copy |
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