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Title: | Sedentary Behaviour and Telomere Length Shortening during Early Childhood: Evidence from the Multicentre Prospective INMA Cohort Study | Authors: | Prieto-Botella, Daniel MARTENS, Dries Valera-Gran, Desiree Subiza-Pérez, Mikel Tardón, Adonina Lozano, Manuel Casas, Maribel Bustamante, Mariona Jimeno-Romero, Alba Fernández-Somoano, Ana Llop, Sabrina Vrijheid, Martine NAWROT, Tim Navarrete-Muñoz, Eva-María |
Issue Date: | 2023 | Publisher: | MDPI | Source: | International Journal of Environmental Research and Public Health, 20 (6) (Art N° 5134) | Abstract: | Sedentary behaviour (SB) may be related to telomere length (TL) attrition due to a possible pro-inflammatory effect. This study examined the association between parent-reported sedentary behaviour (SB) and leukocyte TL at the age of 4 and telomere tracking from 4 to 8 years. In the Spanish birth cohort Infancia y Medio Ambiente (INMA) project, we analysed data from children who attended follow-up visits at age 4 (n = 669) and 8 (n = 530). Multiple robust regression models were used to explore the associations between mean daily hours of SB (screen time, other sedentary activities, and total SB) at 4 years categorised into tertiles and TL at 4 years and difference in TL rank between age 4 and 8, respectively. At the age of 4, the results showed that children with the highest screen time (1.6–5.0 h/day) had a shorter TL of −3.9% (95% CI: −7.4, −0.4; p = 0.03) compared with children in the lowest tertile (0.0–1.0 h/day). Between 4 and 8 years, a higher screen time (highest tertile group vs. lowest tertile) was associated with a decrease in the LTL rank of −1.9% (95% CI: −3.8, −0.1; p = 0.03) from 4 to 8 years. Children exposed to a higher screen time at 4 years were more prone to have shorter TL at 4 and between 4 and 8 years of age. This study supports the potential negative effect of SB during childhood on cellular longevity. | Keywords: | lifestyle;children;genetics;screen time;epigenetics;cellular longevity | Document URI: | http://hdl.handle.net/1942/39778 | ISSN: | 1661-7827 | e-ISSN: | 1660-4601 | DOI: | 10.3390/ijerph20065134 | Rights: | 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/). | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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ijerph-20-05134-v3.pdf | Published version | 673.91 kB | Adobe PDF | View/Open |
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