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Title: | Endothelial function in patients with COPD: an updated systematic review of studies using flow-mediated dilatation | Authors: | Vaes, Anouk W. DE BOEVER, Patrick Franssen, Frits M. E. Uszko-Lencer, Nicole H. M. K. Vanfleteren, Lowie E. G. W. SPRUIT, Martijn A. |
Issue Date: | 2023 | Publisher: | TAYLOR & FRANCIS LTD | Source: | Expert Review of Respiratory Medicine, 17 (1) , p. 53 -69 | Abstract: | IntroductionCardiovascular disease is a significant cause of morbidity and mortality in COPD. Endothelial dysfunction is suggested to be involved in cardiovascular disease pathogenesis, and multiple studies report endothelial dysfunction in COPD. This article summarized the current knowledge on endothelial function in COPD patients.Areas coveredDatabases were screened until November 2022 for studies using ultrasound-based flow-mediated dilation in patients with stable COPD. Pooled effect sizes were calculated using random effects model. Meta-regression analyses assessed the effects of demographic and clinical variables.Expert opinion34 studies were identified (1365 COPD patients; 617 controls). Pooled analysis demonstrated an impaired endothelial-dependent (-2.33%; 95%CI -3.30/-1.35; p < 0.001) and endothelial-independent dilation (-3.11%; 95%CI -5.14/-1.08; p = 0.003) in COPD patients when compared to non-COPD controls. Meta-regression identified that higher age, worse severity of airflow obstruction, and current smoking were significantly associated with impaired endothelial function. Studies evaluating the effects of pharmacological and non-pharmacological interventions on endothelial function in COPD patients demonstrated conflicting results. | Notes: | Vaes, AW (corresponding author), Ciro, Dept Res & Dev, Horn, Netherlands. anoukvaes@ciro-horn.nl |
Keywords: | COPD;cardiovascular disease;endothelial function;flow-mediated dilatation;cardiovascular risk | Document URI: | http://hdl.handle.net/1942/39784 | ISSN: | 1747-6348 | e-ISSN: | 1747-6356 | DOI: | 10.1080/17476348.2023.2176845 | ISI #: | 000935568500001 | Rights: | 2023 Informa UK Limited, trading as Taylor & Francis Group | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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Endothelial function in patients with COPD_ an updated systematic review of studies using flow-media.pdf Restricted Access | Published version | 1.64 MB | Adobe PDF | View/Open Request a copy |
auteursversie.pdf | Peer-reviewed author version | 1.25 MB | Adobe PDF | View/Open |
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