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Title: | Solid-State Crosslinkable, Shape-Memory Polyesters Serving Tissue Engineering | Authors: | Delaey, Jasper Parmentier, Laurens Pyl, Lincy Brancart, Joost ADRIAENSENS, Peter Dobos, Agnes Dubruel, Peter Van Vlierberghe, Sandra |
Issue Date: | 2023 | Publisher: | WILEY-V C H VERLAG GMBH | Source: | MACROMOLECULAR RAPID COMMUNICATIONS, (Art N° 2200955) | Abstract: | Acrylate-endcapped urethane-based precursors constituting a poly(D,L-lactide)/poly(epsilon-caprolactone) (PDLLA/PCL) random copolymer backbone are synthesized with linear and star-shaped architectures and various molar masses. It is shown that the glass transition and thus the actuation temperature could be tuned by varying the monomer content (0-8 wt% epsilon-caprolactone, T-g,T-crosslinked = 10-42 degrees C) in the polymers. The resulting polymers are analyzed for their physico-chemical properties and viscoelastic behavior (G '(max) = 9.6-750 kPa). The obtained polymers are subsequently crosslinked and their shape-memory properties are found to be excellent (R-r = 88-100%, R-f = 78-99.5%). Moreover, their potential toward processing via various additive manufacturing techniques (digital light processing, two-photon polymerization and direct powder extrusion) is evidenced with retention of their shape-memory effect. Additionally, all polymers are found to be biocompatible in direct contact in vitro cell assays using primary human foreskin fibroblasts (HFFs) through MTS assay (up to approximate to 100% metabolic activity relative to TCP) and live/dead staining (>70% viability). | Notes: | Van Vlierberghe, S (corresponding author), Univ Ghent, Ctr Macromol Chem CMaC, Dept Organ & Macromol Chem, Polymer Chem & Biomat Grp PBM, B-9000 Ghent, Belgium.; Van Vlierberghe, S (corresponding author), BIO INX BV, Tech Lane 66, B-9052 Zwijnaarde, Belgium. sandra.vanvlierberghe@ugent.be |
Keywords: | additive manufacturing;digital light processing;polyesters;polyurethanes;shape-memory;two-photon polymerization | Document URI: | http://hdl.handle.net/1942/39852 | ISSN: | 1022-1336 | e-ISSN: | 1521-3927 | DOI: | 10.1002/marc.202200955 | ISI #: | 000937552600001 | Rights: | 2023 Wiley-VCH GmbH | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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Solid‐State Crosslinkable, Shape‐Memory Polyesters Serving Tissue Engineering.pdf Restricted Access | Published version | 3.14 MB | Adobe PDF | View/Open Request a copy |
Delaey et al-fixes-submitted.pdf | Peer-reviewed author version | 2.1 MB | Adobe PDF | View/Open |
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