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Title: | Train your T cells: How skeletal muscles and T cells keep each other fit during aging | Authors: | SLAETS, Leen FONTEYN, Lena OP 'T EIJNDE, Bert HELLINGS, Niels |
Issue Date: | 2023 | Publisher: | ACADEMIC PRESS INC ELSEVIER SCIENCE | Source: | BRAIN BEHAVIOR AND IMMUNITY, 110 , p. 237 -244 | Abstract: | Frailty and a failing immune system lead to significant morbidities in the final years of life and bring along a significant burden on healthcare systems. The good news is that regular exercise provides an effective countermeasure for losing muscle tissue when we age while supporting proper immune system functioning. For a long time, it was assumed that exercise-induced immune responses are predominantly mediated by myeloid cells, but it has become evident that they receive important help from T lymphocytes. Skeletal muscles and T cells interact, not only in muscle pathology but also during exercise. In this review article, we provide an overview of the most important aspects of T cell senescence and discuss how these are modulated by exercise. In addition, we describe how T cells are involved in muscle regeneration and growth. A better understanding of the complex interactions between myocytes and T cells throughout all stages of life provides important insights needed to design strategies that effectively combat the wave of age-related diseases the world is currently faced with. | Notes: | Hellings, N (corresponding author), Hasselt Univ, Biomed Res Inst, Dept Immunol & Infect, Neuroimmune Connect & Repair Lab, Diepenbeek, Belgium.; Hellings, N (corresponding author), UMSC Univ MS Ctr, Campus Diepenbeek, Diepenbeek, Belgium. niels.hellings@uhasselt.be |
Keywords: | Aging;Exercise;T cells;Immune senescence;Muscle;Sarcopenia | Document URI: | http://hdl.handle.net/1942/39941 | ISSN: | 0889-1591 | e-ISSN: | 1090-2139 | DOI: | 10.1016/j.bbi.2023.03.006 | ISI #: | 000956260500001 | Rights: | 2023 Elsevier Inc. All rights reserved. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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Train your T cells_ How skeletal muscles and T cells keep each other fit during aging.pdf Restricted Access | Published version | 2.68 MB | Adobe PDF | View/Open Request a copy |
Train your T cells.pdf | Peer-reviewed author version | 1.27 MB | Adobe PDF | View/Open |
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