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Title: | Lifelong endurance exercise and its relation with coronary atherosclerosis | Authors: | De Bosscher, Ruben Dausin, Christophe Claus, Piet Bogaert, Jan Dymarkowski, Steven Goetschalckx, Kaatje GHEKIERE, Olivier van de Heyning, Caroline M. Van Herck, Paul Paelinck, Bernard El Addouli, Haroun La Gerche, Andre HERBOTS, Lieven Willems , Rik HEIDBUCHEL, Hein CLAESSEN, Guido Claeys, Mathias Hespel, Peter Dresselaers, Tom Miljoen, Hielko Belmans, Ann Favere, Kasper Vermeulen, Dorien Witvrouwen, Isabel HANSEN, Dominique OP 'T EIJNDE, Bert Thijs, Daisy Vanvoorden, Peter Van Soest , Sofie |
Issue Date: | 2023 | Publisher: | OXFORD UNIV PRESS | Source: | EUROPEAN HEART JOURNAL, 44 , p. 2388–2399 | Abstract: | Aims The impact of long-term endurance sport participation (on top of a healthy lifestyle) on coronary atherosclerosis and acute cardiac events remains controversial. Methods and results The Master@Heart study is a well-balanced prospective observational cohort study. Overall, 191 lifelong master endurance athletes, 191 late-onset athletes (endurance sports initiation after 30 years of age), and 176 healthy non-athletes, all male with a low cardiovascular risk profile, were included. Peak oxygen uptake quantified fitness. The primary endpoint was the prevalence of coronary plaques (calcified, mixed, and non-calcified) on computed tomography coronary angiography. Analyses were corrected for multiple cardiovascular risk factors. The median age was 55 (50-60) years in all groups. Lifelong and late-onset athletes had higher peak oxygen uptake than non-athletes [159 (143-177) vs. 155 (138-169) vs. 122 (108-138) % predicted]. Lifelong endurance sports was associated with having >= 1 coronary plaque [odds ratio (OR) 1.86, 95% confidence interval (CI) 1.17-2.94], >= 1 proximal plaque (OR 1.96, 95% CI 1.24-3.11), >= 1 calcified plaques (OR 1.58, 95% CI 1.01-2.49), >= 1 calcified proximal plaque (OR 2.07, 95% CI 1.28-3.35), >= 1 non-calcified plaque (OR 1.95, 95% CI 1.12-3.40), >= 1 non-calcified proximal plaque (OR 2.80, 95% CI 1.39-5.65), and >= 1 mixed plaque (OR 1.78, 95% CI 1.06-2.99) as compared to a healthy non-athletic lifestyle. Conclusion Lifelong endurance sport participation is not associated with a more favourable coronary plaque composition compared to a healthy lifestyle. Lifelong endurance athletes had more coronary plaques, including more non-calcified plaques in proximal segments, than fit and healthy individuals with a similarly low cardiovascular risk profile. Longitudinal research is needed to reconcile these findings with the risk of cardiovascular events at the higher end of the endurance exercise spectrum. [GRAPHICS] . | Notes: | Claessen, G (corresponding author), Katholieke Univ Leuven, Dept Cardiovasc Sci, Herestr 49, B-3000 Leuven, Belgium.; Claessen, G (corresponding author), Univ Hasselt, Dept Med & Life Sci, Stadsomvaart 11, B-3500 Hasselt, Belgium.; Claessen, G (corresponding author), Baker Heart & Diabet Inst, Dept Cardiol, 75 Commercial Rd, Melbourne, Vic 3004, Australia.; Claessen, G (corresponding author), Jessa Ziekenhuis, Div Cardiol, Hartctr, Stadsomvaart 11, B-3500 Hasselt, Belgium. claessen.guido@gmail.com |
Keywords: | Athlete's heart;Exercise;Coronary artery disease;Computed tomography coronary angiography | Document URI: | http://hdl.handle.net/1942/39955 | ISSN: | 0195-668X | e-ISSN: | 1522-9645 | DOI: | 10.1093/eurheartj/ehad152 | ISI #: | 000952021400001 | Rights: | The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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