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http://hdl.handle.net/1942/39971
Title: | Hybrid Hydrogels with Orthogonal Transient Cross-linking Exhibiting Highly Tunable Mechanical Properties | Authors: | HOUBEN, Sofie Aldana, Ana A. Huysecom, An-Sofie Mpinganzima, Winy Cardinaels, Ruth Baker, Matthew B. PITET, Louis |
Issue Date: | 2023 | Publisher: | AMER CHEMICAL SOC | Source: | ACS Applied Polymer Materials, 5 (3) , p. 1819 -1827 | Abstract: | Compositional changes in the chemical makeup of hydrogels offer a powerful strategy for fine tuning of mechanical properties, enabling specific targeting for different applications. The chemical versatility exhibited by the tunable system introduced here can be leveraged to address a broad range of characteristics across the field of tissue engineering-from blood vessels to cartilage, for example-which demands materials with very different mechanical profiles. Furthermore, we rely exclusively on dynamic, non-covalent cross-linking to provide opportunities for 3D printing and injectability. This work describes a highly tunable system based on hydrogen bonding and ionic interactions. Single network hydrogels were made by exploiting various acrylic monomers including N-acryloyl glycinamide (NAGA) and acrylic acid (AAc). Additionally, hybrid hydrogels were explored by combining these acrylic networks with an ionically cross-linked alginate network. By combining orthogonal cross-linking strategies and altering the ratio between different components in these hybrid gels, a broad range of mechanical properties is demonstrated. The characteristics were extensively investigated using tensile testing, compression testing, and rheological measurements. The final scaffolds were also shown to be non-cytotoxic in preliminary cell viability studies for human dermal fibroblasts. | Notes: | Pitet, LM (corresponding author), Hasselt Univ, Inst Mat Res Imo Imomec, Adv Funct Polymers AFP Grp, B-3500 Hasselt, Belgium.; Baker, MB (corresponding author), Maastricht Univ, MERLN Inst Technol Inspired Regenerat Med, Dept Complex Tissue Regenerat, NL-6200 MD Maastricht, Netherlands. m.baker@maastrichtuniversity.nl; Louis.pitet@uhasselt.be |
Keywords: | interpenetrating network hydrogels;hybrid hydrogels;dynamic crosslinking;tissue engineering | Document URI: | http://hdl.handle.net/1942/39971 | ISSN: | 2637-6105 | e-ISSN: | 2637-6105 | DOI: | 10.1021/acsapm.2c01906 | ISI #: | 000952982600001 | Rights: | 2023 American Chemical Society | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Hybrid Hydrogels with Orthogonal Transient Cross-linking Exhibiting Highly Tunable Mechanical Properties.pdf Restricted Access | Published version | 9.37 MB | Adobe PDF | View/Open Request a copy |
NAGA_Manuscript_Clean_2ndRev.pdf | Peer-reviewed author version | 10.19 MB | Adobe PDF | View/Open |
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