Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/39972
Title: | Abnormal thalamic functional connectivity correlates with cardiorespiratory fitness and physical activity in progressive multiple sclerosis | Authors: | Romano, Francesco Motl, Robert W. Valsasina, Paola Amato, Maria Pia Brichetto, Giampaolo Bruschi, Nicolo Chataway, Jeremy Chiaravalloti, Nancy D. Cutter, Gary Dalgas, Ulrik DeLuca, John Farrell, Rachel FEYS, Peter Freeman, Jennifer Inglese, Matilde Meza, Cecilia Salter, Amber Sandroff, Brian M. Feinstein, Anthony Rocca , Maria A. Filippi, Massimo CogEx Res Team, CogEx Res Team |
Issue Date: | 2023 | Publisher: | SPRINGER HEIDELBERG | Source: | JOURNAL OF NEUROLOGY, 270 (6) , p. 3213-3224 | Abstract: | BackgroundAltered thalamic volumes and resting state (RS) functional connectivity (FC) might be associated with physical activity (PA) and cardiorespiratory fitness (CRF) in people with progressive multiple sclerosis (PMS).ObjectivesTo assess thalamic structural and functional alterations and investigate their correlations with PA/CRF levels in people with PMS.MethodsSeven-day accelerometry and cardiopulmonary exercise testing were used to assess PA/CRF levels in 91 persons with PMS. They underwent 3.0 T structural and RS fMRI acquisition with 37 age/sex-matched healthy controls (HC). Between-group comparisons of MRI measures and their correlations with PA/CRF variables were assessed.ResultsPMS people had lower volumes compared to HC (all p < 0.001). At corrected threshold, PMS showed decreased intra- and inter-thalamic RS FC, and increased RS FC between the thalamus and the hippocampus, bilaterally. At uncorrected threshold, decreased thalamic RS FC with caudate nucleus, cerebellum and anterior cingulate cortex (ACC), as well as increased thalamic RS FC with occipital regions, were also detected. Lower CRF, measured as peak oxygen consumption (VO2peak), correlated with lower white matter volume (r = 0.31, p = 0.03). Moreover, lower levels of light PA correlated with increased thalamic RS FC with the right hippocampus (r = - 0.3, p = 0.05).DiscussionPeople with PMS showed widespread brain atrophy, as well as pronounced intra-thalamic and thalamo-hippocampal RS FC abnormalities. White matter atrophy correlated with CRF, while increased thalamo-hippocampal RS FC was associated to worse PA levels. Thalamic RS FC might be used to monitor physical impairment and efficacy of rehabilitative and disease-modifying treatments in future studies. | Notes: | Filippi, M (corresponding author), IRCCS San Raffaele Sci Inst, Div Neurosci, Neuroimaging Res Unit, Via Olgettina 60, I-20132 Milan, Italy.; Filippi, M (corresponding author), IRCCS San Raffaele Sci Inst, Neurol Unit, Milan, Italy.; Filippi, M (corresponding author), Univ Vita Salute San Raffaele, Milan, Italy. filippi.massimo@hsr.it |
Keywords: | Fitness;Functional connectivity;MRI;Multiple sclerosis;Physical activity;Thalamus | Document URI: | http://hdl.handle.net/1942/39972 | ISSN: | 0340-5354 | e-ISSN: | 1432-1459 | DOI: | 10.1007/s00415-023-11664-8 | ISI #: | 000952232500001 | Rights: | The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2023 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Abnormal thalamic functional connectivity correlates with cardiorespiratory fitness and physical activity in progressive multiple sclerosis.pdf Restricted Access | Published version | 879.72 kB | Adobe PDF | View/Open Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.