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Title: | Bayesian Borrowing Methods for Count Data: Analysis of Incontinence Episodes in Patients with Overactive Bladder | Authors: | Banbeta, Akalu LESAFFRE, Emmanuel Martina, Reynaldo van Rosmalen, Joost |
Issue Date: | 2023 | Publisher: | TAYLOR & FRANCIS INC | Source: | Statistics in Biopharmaceutical Research, | Status: | Early view | Abstract: | We examine the performance of the power prior and the meta-analytic-predictive (MAP) prior for the analysis of (overdispersed) count data when multiple historical control data are incorporated into the analysis of the current data. To this end, we explore the Poisson and the negative binomial distribution. We propose a computational approach based on path sampling for the calculation of the scaling constant of the Modified Power Prior (MPP). We illustrate the methods through a motivating example of a clinical trial evaluating the effect of an experimental treatment to reduce the number of incontinence events for patients with an overactive bladder. Furthermore, we assess the performance of these methods via a simulation study in case of heterogeneity of the control arms. For similar current and historical control arms, the MPP approach offers greater statistical power than the MAP prior approach. When the means are different across the control arms, the MPP yields a slightly inflated Type I error rate, whereas the MAP prior does not. When the dispersion parameters are different across the control arms, the results are reversed. In conclusion, the MPP approach outperforms the MAP prior approach for count data. | Notes: | Banbeta, A (corresponding author), UHasselt, I Biostat, Hasselt, Belgium. akalubanbetastat@gmail.com |
Keywords: | Meta-analytic predictive prior;Negative binomial;Overdispersion;Poisson;Power prior | Document URI: | http://hdl.handle.net/1942/40042 | ISSN: | 1946-6315 | e-ISSN: | 1946-6315 | DOI: | 10.1080/19466315.2023.2190933 | ISI #: | 000973336400001 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Manuscript_SBR_Dec_16_2022.pdf | Peer-reviewed author version | 499.5 kB | Adobe PDF | View/Open |
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