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http://hdl.handle.net/1942/40141| Title: | Seroconversion rate after primary vaccination with two doses of BNT162b2 versus mRNA-1273 in solid organ transplant recipients: a systematic review and meta-analysis | Authors: | Verleye, Arno Wijtvliet, Veerle ABRAMS, Steven Hellemans, Rachel Bougrea, Rania Massart, Annick Pipeleers, Lissa Wissing, Karl Martin Ariën, Kevin K De Winter, Benedicte Y Van Damme, Pierre Abramowicz, Daniel Ledeganck, Kristien J |
Issue Date: | 2022 | Publisher: | Source: | Nephrology, dialysis, transplantation, 37 (8) , p. 1566 -1575 | Abstract: | Background.Inthegeneralpopulation,theseroconversion rateafterprimaryvaccinationwithtwodosesofanantisevereacuterespiratorysyndromecoronavirus2messenger RNA(mRNA)vaccinereachesnearly100%,withsignificantly higherantibodytitersaftermRNA-1273vaccinationcompared toBNT162b2vaccination.Hereweperformedasystematic reviewandmeta-analysistocomparetheantibodyresponse aftertwo-dosemRNA-1273versusBNT162b2vaccinationin solidorgantransplant(SOT)recipients. Methods.Asystematicliteraturereviewwasperformedusing PubMed,WebofScienceandtheCochraneLibraryand originalresearchpaperswereincludedforameta-analysisto calculatevaccine-specificseroconversionratesforeachofthe mRNAvaccines.Next,thepooledrelativeseroconversionrate wasestimated. Results.Eightstudiesthatdescribedthedevelopmentofantibodiesagainstreceptor-bindingdomain(RBD)and/orspike proteinwereeligibleformeta-analysis.Twoofthesestudies alsoreportedantibodytiters.Themeta-analysisrevealedlower seroconversionratesinSOTrecipientsvaccinatedwithtwo dosesofBNT162b2{44.3%[95%confidenceinterval(CI) 34.1–54.7]}ascomparedwithpatientsvaccinatedwithtwo dosesofmRNA-1273[58.4%(95%CI47.2–69.2)].Therelative seroconversionratewas0.795(95%CI0.732–0.864). Conclusions.Thissystematicreviewandmeta-analysis indicatesthatinSOTrecipients,higherseroconversionrates wereobservedaftervaccinationwithmRNA-1273compared withBNT162b2. | Document URI: | http://hdl.handle.net/1942/40141 | ISSN: | 0931-0509 | e-ISSN: | 1460-2385 | DOI: | 10.1093/ndt/gfac174 | Rights: | The Author(s) 2022.Published by Oxford University Presson behalf of the ERA. Allrights reserved. For permissions, please e-mail: journals.permissions@oup.com. Free access | Category: | A1 | Type: | Journal Contribution | Validations: | vabb 2024 |
| Appears in Collections: | Research publications |
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| Seroconversion rate after primary vaccination with two doses of BNT162b2 versus mRNA-1273.pdf | Published version | 772.2 kB | Adobe PDF | View/Open |
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