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Title: | Revisiting the role of acute kidney injury in patients on immune checkpoint inhibitors: a good prognosis renal event with a significant impact on survival | Authors: | Garcia-Carro, Clara Jhaveri, Kenar D. SPRANGERS, Ben |
Issue Date: | 2023 | Publisher: | OXFORD UNIV PRESS | Source: | Clinical Kidney Journal, 16 (5) , p. 773 -775 | Abstract: | In the last decade, immune checkpoint inhibitors (ICI) have become a cornerstone in the treatment of a wide range of malignancies. It is well established that ICI are associated with multiple immune-related adverse events, a spectrum of autoimmune toxicities, that can also affect the kidney. In this issue of Clinical Kidney Journal, Kanbay et al. report the first meta-analysis and systematic review evaluating the impact of ICI-related acute kidney injury (ICI-AKI) on long-term kidney and patient outcomes (including mortality). The authors report a high incidence of ICI-AKI (mostly mild AKI episodes) with high rates of recovery resulting in a good kidney outcomes. However, the occurrence of ICI-AKI has a significant impact on mortality in ICI-treated patients probably related to temporary or definitive cessation of ICI. Additional studies are needed to establish the safety of ICI re-challenging in patients with ICI-AKI, and to determine the optimal treatment strategy for them. | Notes: | Sprangers, B (corresponding author), Ziekenhuis Oost Limburg, Dept Med, Div Nephrol, Genk, Belgium.; Sprangers, B (corresponding author), Biomed Res Inst, Dept Immunol & Infect, Diepenbeek, Belgium. ben.sprangers@zol.be |
Keywords: | acute kidney injury;immune checkpoint inhibitors;immune-related adverse events;mortality;onconephrology | Document URI: | http://hdl.handle.net/1942/40177 | ISSN: | 2048-8505 | e-ISSN: | 2048-8513 | DOI: | 10.1093/ckj/sfad035 | ISI #: | 000979293500001 | Rights: | The Author(s) 2023. Published by Oxford University Press on behalf of the ERA. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com | Category: | A2 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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