Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/40227
Full metadata record
DC FieldValueLanguage
dc.contributor.authorRasooli, Amirhossein-
dc.contributor.authorAdab, Hamed Zivari-
dc.contributor.authorVan Ruitenbeek, Peter-
dc.contributor.authorWeerasekera, Akila-
dc.contributor.authorChalavi, Sima-
dc.contributor.authorCUYPERS, Koen-
dc.contributor.authorLevin, Oron-
dc.contributor.authorDhollander, Thijs-
dc.contributor.authorPeeters, Ronald-
dc.contributor.authorSunaert, Stefan-
dc.contributor.authorMantini, Dante-
dc.contributor.authorSwinnen, Stephan P.-
dc.date.accessioned2023-05-31T10:50:19Z-
dc.date.available2023-05-31T10:50:19Z-
dc.date.issued2023-
dc.date.submitted2023-05-24T09:25:36Z-
dc.identifier.citationiScience, 26 (6) (Art N° 106794)-
dc.identifier.issn25890042-
dc.identifier.urihttp://hdl.handle.net/1942/40227-
dc.description.abstractAgingisassociatedwithchangesinthecentralnervoussystemandleadsto reducedlifequality.Here,weinvestigatedtheage-relateddifferencesinthe CNSunderlyingmotorperformancedeficitsusingmagneticresonancespectroscopyanddiffusionMRI.MRSmeasuredN-acetylaspartate(NAA),choline(Cho), andcreatine(Cr)concentrationsinthesensorimotorandoccipitalcortex, whereasdMRIquantifiedapparentfiberdensity(FD)inthesamevoxelstoevaluatewhitemattermicrostructuralorganization.WefoundthatagingwasassociatedwithincreasedreactiontimeandreducedFDandNAAconcentrationinthe sensorimotorvoxel.BothFDandNAAmediatedtheassociationbetweenage andreactiontime.TheNAAconcentrationwasfoundtomediatetheassociation betweenageandFDinthesensorimotorvoxel.Weproposethattheage-related decreaseinNAAconcentrationmayresultinreducedaxonalfiberdensityinthe sensorimotorcortexwhichmayultimatelyaccountfortheresponseslownessof olderparticipants.-
dc.description.sponsorshipWethankallparticipantsfortakingpartinthisstudy,PaulMeugensfortaskdeviceconstruction,andRene´ Clerckxforprogrammingthebehavioraltask.ThisworkwassupportedbytheResearchFoundationFlanders(G089818N,K174216N),theExcellenceSciencegrant(EOS,30446199,MEMODYN),andtheKU LeuvenResearchFund(C16/15/070).-
dc.language.isoen-
dc.publisherCell Press-
dc.rights2023 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).-
dc.subject.otherCognitive neuroscience-
dc.subject.otherNeuroscience-
dc.subject.otherPhysics magnetic resonance imaging-
dc.titleWhite matter and neurochemical mechanisms underlying age-related differences in motor processing speed-
dc.typeJournal Contribution-
dc.identifier.issue6-
dc.identifier.volume26-
local.format.pages20-
local.bibliographicCitation.jcatA1-
local.publisher.place50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.artnr106794-
dc.identifier.doi10.1016/j.isci.2023.106794-
dc.identifier.pmid37255665-
dc.identifier.isi001021263500001-
dc.identifier.eissn2589-0042-
local.provider.typePdf-
local.uhasselt.internationalyes-
item.contributorRasooli, Amirhossein-
item.contributorAdab, Hamed Zivari-
item.contributorVan Ruitenbeek, Peter-
item.contributorWeerasekera, Akila-
item.contributorChalavi, Sima-
item.contributorCUYPERS, Koen-
item.contributorLevin, Oron-
item.contributorDhollander, Thijs-
item.contributorPeeters, Ronald-
item.contributorSunaert, Stefan-
item.contributorMantini, Dante-
item.contributorSwinnen, Stephan P.-
item.accessRightsOpen Access-
item.fullcitationRasooli, Amirhossein; Adab, Hamed Zivari; Van Ruitenbeek, Peter; Weerasekera, Akila; Chalavi, Sima; CUYPERS, Koen; Levin, Oron; Dhollander, Thijs; Peeters, Ronald; Sunaert, Stefan; Mantini, Dante & Swinnen, Stephan P. (2023) White matter and neurochemical mechanisms underlying age-related differences in motor processing speed. In: iScience, 26 (6) (Art N° 106794).-
item.validationecoom 2024-
item.fulltextWith Fulltext-
crisitem.journal.eissn2589-0042-
Appears in Collections:Research publications
Files in This Item:
File Description SizeFormat 
1-s2.0-S2589004223008714-main.pdfPublished version4.55 MBAdobe PDFView/Open
Show simple item record

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.