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http://hdl.handle.net/1942/40227| Title: | White matter and neurochemical mechanisms underlying age-related differences in motor processing speed | Authors: | Rasooli, Amirhossein Adab, Hamed Zivari Van Ruitenbeek, Peter Weerasekera, Akila Chalavi, Sima CUYPERS, Koen Levin, Oron Dhollander, Thijs Peeters, Ronald Sunaert, Stefan Mantini, Dante Swinnen, Stephan P. |
Issue Date: | 2023 | Publisher: | Cell Press | Source: | iScience, 26 (6) (Art N° 106794) | Abstract: | Agingisassociatedwithchangesinthecentralnervoussystemandleadsto reducedlifequality.Here,weinvestigatedtheage-relateddifferencesinthe CNSunderlyingmotorperformancedeficitsusingmagneticresonancespectroscopyanddiffusionMRI.MRSmeasuredN-acetylaspartate(NAA),choline(Cho), andcreatine(Cr)concentrationsinthesensorimotorandoccipitalcortex, whereasdMRIquantifiedapparentfiberdensity(FD)inthesamevoxelstoevaluatewhitemattermicrostructuralorganization.WefoundthatagingwasassociatedwithincreasedreactiontimeandreducedFDandNAAconcentrationinthe sensorimotorvoxel.BothFDandNAAmediatedtheassociationbetweenage andreactiontime.TheNAAconcentrationwasfoundtomediatetheassociation betweenageandFDinthesensorimotorvoxel.Weproposethattheage-related decreaseinNAAconcentrationmayresultinreducedaxonalfiberdensityinthe sensorimotorcortexwhichmayultimatelyaccountfortheresponseslownessof olderparticipants. | Keywords: | Cognitive neuroscience;Neuroscience;Physics magnetic resonance imaging | Document URI: | http://hdl.handle.net/1942/40227 | e-ISSN: | 2589-0042 | DOI: | 10.1016/j.isci.2023.106794 | ISI #: | 001021263500001 | Rights: | 2023 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2024 |
| Appears in Collections: | Research publications |
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| 1-s2.0-S2589004223008714-main.pdf | Published version | 4.55 MB | Adobe PDF | View/Open |
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