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Title: | Risk Factors for Short-Term Versus Long-Term Mortality in Patients Who Underwent Cardiac Resynchronization Therapy | Authors: | Galloo, Xavier Khidir, Mand STASSEN, Jan Hirasawa, Kensuke Cosyns, Bernard van der Bijl, Pieter Delgado, Victoria Marsan, Nina Ajmone Bax, Jeroen J. |
Issue Date: | 2023 | Publisher: | EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC | Source: | AMERICAN JOURNAL OF CARDIOLOGY, 197 , p. 34 -41 | Abstract: | Cardiac resynchronization therapy (CRT) is an effective therapy in selected patients with advanced heart failure that reduces all-cause mortality at short-term follow-up. However, data regarding long-term mortality after CRT implantation are scarce, with no separate analysis available of the covariates associated with respectively short-term and long-term outcomes. Accordingly, the present study evaluated the risk factors associated with short-term (2-year follow-up) versus long-term (10-year follow-up) mortality after CRT implan-tation. Patients who underwent CRT implantation and had echocardiographic evaluation before implantation were included in the present study. The primary end point was all-cause mortality, and independent associates of short-term (2-year follow-up) and long-term (10-year follow-up) mortality were compared. In total, 894 patients (mean age 66 </n> 10 years, 76% males) who underwent CRT implantation were included in the present study. The cumulative overall survival rates for the total population were 91%, 71%, and 45% at 2-, 5-and 10-year follow-up, respectively. Multivariable Cox regression analysis showed that short-term mortality was associated with both clinical and echocardiographic variables at the moment of CRT implantation; whereas long-term mortality was predomi-nantly associated with baseline clinical parameters and was less strongly associated with baseline echocardiographic parameters. In conclusion, at long-term (10-year) follow-up, a significant proportion (45%) of patients with advanced heart failure who underwent CRT implantation were still alive. Importantly, the risk assessment for short-term (2-year fol-low-up) and long-term (10-year follow-up) mortality differ considerably, which may influ-ence clinical decision making. (c) 2023 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/ 4.0/) (Am J Cardiol 2023;197:34-41) | Notes: | Bax, JJ (corresponding author), Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands.; Bax, JJ (corresponding author), Univ Turku, Heart Ctr, Turku, Finland.; Bax, JJ (corresponding author), Turku Univ Hosp, Turku, Finland. J.J.Bax@lumc.nl |
Keywords: | Male;Humans;Middle Aged;Aged;Female;Prognosis;Risk Factors;Survival Rate;Treatment Outcome;Cardiac Resynchronization Therapy;Heart Failure;Defibrillators, Implantable | Document URI: | http://hdl.handle.net/1942/40363 | ISSN: | 0002-9149 | e-ISSN: | 1879-1913 | DOI: | 10.1016/j.amjcard.2023.03.026 | ISI #: | 000994052900001 | Rights: | The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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