Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/40675
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dc.contributor.authorPINCELA LINS, Paula-
dc.contributor.authorPIRLET, Elke-
dc.contributor.authorSzymonik, Michal-
dc.contributor.authorBRONCKAERS, Annelies-
dc.contributor.authorNelissen, Inge-
dc.date.accessioned2023-08-04T06:49:46Z-
dc.date.available2023-08-04T06:49:46Z-
dc.date.issued2023-
dc.date.submitted2023-08-03T15:10:58Z-
dc.identifier.citationTRENDS IN BIOTECHNOLOGY, 41 (7) , p. 965 -981-
dc.identifier.urihttp://hdl.handle.net/1942/40675-
dc.description.abstractMesenchymal stromal cells (MSCs) are a promising therapy for various diseases ranging from ischemic stroke to wound healing and cancer. Their therapeutic effects are mainly mediated by secretome-derived paracrine factors, with extracellular vesicles (EVs) proven to play a key role. This has led to promising research on the potential of MSC-EVs as regenerative, off-the-shelf therapeutic agents. However, the translation of MSC-EVs into the clinic is hampered by the poor scalability of their production. Recently, new advanced methods have been developed to upscale MSC cultivation and EV production yields, ranging from new cell culture devices to priming procedures. This review gives an overview of these innovative strategies for manufacturing MSC-EVs.-
dc.language.isoen-
dc.publisherCELL PRESS-
dc.subject.otherextracellular vesicles-
dc.subject.othermesenchymal stromal cells-
dc.subject.otherbioreactor-
dc.subject.otherupscaled manufacturing-
dc.titleManufacture of extracellular vesicles derived from mesenchymal stromal cells-
dc.typeJournal Contribution-
dc.identifier.epage981-
dc.identifier.issue7-
dc.identifier.spage965-
dc.identifier.volume41-
local.bibliographicCitation.jcatA1-
local.publisher.place50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA-
local.type.refereedRefereed-
local.type.specifiedReview-
dc.identifier.doi10.1016/j.tibtech.2023.01.003-
dc.identifier.isiWOS:001027534500001-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0167779923000203-
local.provider.typeris-
local.uhasselt.internationalno-
item.fullcitationPINCELA LINS, Paula; PIRLET, Elke; Szymonik, Michal; BRONCKAERS, Annelies & Nelissen, Inge (2023) Manufacture of extracellular vesicles derived from mesenchymal stromal cells. In: TRENDS IN BIOTECHNOLOGY, 41 (7) , p. 965 -981.-
item.contributorPINCELA LINS, Paula-
item.contributorPIRLET, Elke-
item.contributorSzymonik, Michal-
item.contributorBRONCKAERS, Annelies-
item.contributorNelissen, Inge-
item.fulltextWith Fulltext-
item.accessRightsRestricted Access-
crisitem.journal.issn0167-7799-
crisitem.journal.eissn1879-3096-
Appears in Collections:Research publications
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