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http://hdl.handle.net/1942/40675
Title: | Manufacture of extracellular vesicles derived from mesenchymal stromal cells | Authors: | PINCELA LINS, Paula PIRLET, Elke Szymonik, Michal BRONCKAERS, Annelies Nelissen, Inge |
Issue Date: | 2023 | Publisher: | CELL PRESS | Source: | TRENDS IN BIOTECHNOLOGY, 41 (7) , p. 965 -981 | Abstract: | Mesenchymal stromal cells (MSCs) are a promising therapy for various diseases ranging from ischemic stroke to wound healing and cancer. Their therapeutic effects are mainly mediated by secretome-derived paracrine factors, with extracellular vesicles (EVs) proven to play a key role. This has led to promising research on the potential of MSC-EVs as regenerative, off-the-shelf therapeutic agents. However, the translation of MSC-EVs into the clinic is hampered by the poor scalability of their production. Recently, new advanced methods have been developed to upscale MSC cultivation and EV production yields, ranging from new cell culture devices to priming procedures. This review gives an overview of these innovative strategies for manufacturing MSC-EVs. | Keywords: | extracellular vesicles;mesenchymal stromal cells;bioreactor;upscaled manufacturing | Document URI: | http://hdl.handle.net/1942/40675 | Link to publication/dataset: | https://www.sciencedirect.com/science/article/pii/S0167779923000203 | ISSN: | 0167-7799 | e-ISSN: | 1879-3096 | DOI: | 10.1016/j.tibtech.2023.01.003 | ISI #: | WOS:001027534500001 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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1-s2.0-S0167779923000203-main.pdf Restricted Access | Published version | 2.34 MB | Adobe PDF | View/Open Request a copy |
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