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Title: | Analysis of linearized elasticity models with point sources in weighted Sobolev spaces: applications in tissue contraction | Authors: | Boon, Wietse M. VERMOLEN, Fred |
Issue Date: | 2023 | Publisher: | EDP SCIENCES S A | Source: | ESAIM-Mathematical Modelling and Numerical Analysis, 57 (4) , p. 2349 -2370 | Abstract: | In order to model the contractive forces exerted by fibroblast cells in dermal tissue, we propose and analyze two modeling approaches under the assumption of linearized elasticity. The first approach introduces a collection of point forces on the boundary of the fibroblast whereas the second approach employs an isotropic stress point source in its center. We analyze the resulting partial differential equations in terms of weighted Sobolev spaces and identify the singular behavior of the respective solutions. Two finite element method approaches are proposed, one based on a direct application and another in which the singularity is subtracted and a correction field is computed. Finally, we confirm the validity of the modeling approach, demonstrate convergence of the numerical methods, and verify the analysis through the use of numerical experiments. | Notes: | Boon, WM (corresponding author), Politecn Milan, Lab Modeling & Sci Comp MOX, P Za Leonardo Vinci 32, I-20133 Milan, Italy. wietsemarijn.boon@polimi.it |
Keywords: | Point source;weighted Sobolev space;linearized elasticity | Document URI: | http://hdl.handle.net/1942/40743 | ISSN: | 2822-7840 | e-ISSN: | 2804-7214 | DOI: | 10.1051/m2an/2023055 | ISI #: | 001030707900001 | Rights: | The authors. Published by EDP Sciences, SMAI 2023. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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