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http://hdl.handle.net/1942/40783
Title: | Heart rate variability is not suitable as a surrogate marker for pain intensity in patients with chronic pain | Authors: | Moens, Maarten Billet, Bart MOLENBERGHS, Geert De Smedt, Ann Pilitsis, Julie G. De Vos, Ruben Hanssens, Karel Billot, Maxime Roulaud, Manuel Rigoard, Philippe Goudman, Lisa |
Issue Date: | 2023 | Publisher: | LIPPINCOTT WILLIAMS & WILKINS | Source: | PAIN, 164 (8) , p. 1741 -1749 | Abstract: | The search towards more objective outcome measurements and consequently surrogate markers for pain started decades ago; however, no generally accepted biomarker for pain has qualified yet. The goal is to explore the value of heart rate variability (HRV) as surrogate marker for pain intensity chronic pain setting. Pain intensity scores and HRV were collected in 366 patients with chronic pain, through a cross-sectional multicenter study. Pain intensity was measured with both the visual analogue scale and numeric rating scale, whereas 16 statistical HRV parameters were derived. Canonical correlation analysis was performed to evaluate the correlation between the dependent pain variables and the HRV parameters. Surrogacy was determined for each HRV parameter with point estimates between 0 and 1 whereby values close to 1 indicate a strong association between the surrogate and the true endpoint at the patient level. Weak correlations were revealed between HRV parameters and pain intensity scores. The highest surrogacy point estimate was found for mean heart rate as marker for average pain intensity on the numeric rating scale with point estimates of 0.0961 (95% confidence interval [CI] 0.0384-0.1537) and 0.0209 (95% CI 0-0.05) for patients without medication use and with medication, respectively. This study indicated that HRV parameters as separate entities are no suitable surrogacy candidates for pain intensity, in a population of chronic pain patients. Further potential surrogate candidates and clinical robust true endpoints should be explored, to find a surrogate measure for the highly individual pain experience. | Notes: | Goudman, L (corresponding author), Vrije Univ Brussel, Ctr Neurosci C4N, Brussels, Belgium.; Goudman, L (corresponding author), Vrije Univ Brussel, STIMULUS Res Grp, Laarbeeklaan 103, B-1090 Jette, Belgium. mtmoens@gmail.com; bart.billet@azdelta.be; geert.molenberghs@uhasselt.be; Ann.DeSmedt@uzbrussel.be; jpilitsis@health.fau.edu; ruben.devos@azdelta.be; karel.hanssens@azdelta.be; Maxime.BILLOT@chu-poitiers.fr; Manuel.ROULAUD@chu-poitiers.fr; Philippe.RIGOARD@chu-poitiers.fr; lisa.goudman@vub.be |
Keywords: | Biomarker;Surrogacy;Chronic pain;Autonomic nervous system;Pain management | Document URI: | http://hdl.handle.net/1942/40783 | ISSN: | 0304-3959 | e-ISSN: | 1872-6623 | DOI: | 10.1097/j.pain.0000000000002868 | ISI #: | 001030779300011 | Rights: | 2023 International Association for the Study of Pain http://dx.doi.org/10.1097/j.pain.0000000000002868 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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PAIN-D-22-00868 1741..1749.pdf Restricted Access | Published version | 393.83 kB | Adobe PDF | View/Open Request a copy |
644a.pdf | Peer-reviewed author version | 1.38 MB | Adobe PDF | View/Open |
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