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Title: | Dopamine-mediated striatal activity and function is enhanced in GlyR alpha 2 knockout animals | Authors: | DEVOGHT, Jens COMHAIR, Joris MORELLI, Giovanni RIGO, Jean-Michel D'Hooge, Rudi Touma, Chadi Palme, Rupert DEWACHTER, Ilse VAN DE VEN, Martin Harvey, Robert J. Schiffmann, Serge N. PICCART, Elisabeth BRONE, Bert |
Issue Date: | 2023 | Publisher: | CELL PRESS | Source: | iScience, 26 (8) (Art N° 107400) | Abstract: | The glycine receptor alpha 2 (GlyR alpha 2) is a ligand-gated ion channel which upon activation induces a chloride conductance. Here, we investigated the role of GlyRa2 in dopamine-stimulated striatal cell activity and behavior. We show that depletion of GlyR alpha 2 enhances dopamine-induced increases in the activity of putative dopamine D1 receptor-expressing striatal projection neurons, but does not alter midbrain dopamine neuron activity. We next show that the locomotor response to d-amphetamine is enhanced in GlyRa2 knockout animals, and that this increase correlates with c-fos expression in the dorsal striatum. 3-Dmodeling revealed an increase in the neuronal ensemble size in the striatum in response to D-amphetamine in GlyR alpha 2 KO mice. Finally, we show enhanced appetitive conditioning in GlyR alpha 2 KO animals that is likely due to increased motivation, but not changes in associative learning or hedonic response. Taken together, we show that GlyR alpha 2 is an important regulator of dopamine-stimulated striatal activity and function. | Notes: | Brone, B (corresponding author), UHasselt, Dept Neurosci, B-3500 Hasselt, Belgium. bert.brone@uhasselt.be |
Keywords: | Behavioral neuroscience;Neuroscience | Document URI: | http://hdl.handle.net/1942/40878 | e-ISSN: | 2589-0042 | DOI: | 10.1016/j.isci.2023.107400 | ISI #: | 001057338000001 | Rights: | 2023 Crown Copyright. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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