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Title: | Early Neuromuscular Electrical Stimulation Preserves Muscle Size and Quality and Maintains Systemic Levels of Signaling Mediators of Muscle Growth and Inflammation in Patients with Traumatic Brain Injury: A Randomized Clinical Trial | Authors: | Vieira, Luciana Silva, Paulo Eugenio de Melo, Priscilla Flavia Maldaner, Vinicius Durigan, Joao Q. Marqueti, Rita de Cassia Nobrega, Otavio Mathur, Sunita BURTIN, Chris Barin, Fabricio Machado-Silva, Wilcelly Ramalho, Sergio Chiappa, Gaspar R. Gomes, Nadia Oliveira Carvalho, Celso R. F. Cipriano, Graziella F. B. Cipriano, Gerson |
Editors: | Luchette, Fred A. | Issue Date: | 2023 | Publisher: | HINDAWI LTD | Source: | Critical Care Research and Practice, 2023 , p. 1 -12 (Art N° ID 9335379) | Abstract: | Objective. To investigate the effects of an early neuromuscular electrical stimulation (NMES) protocol on muscle quality and size as well as signaling mediators of muscle growth and systemic inflammation in patients with traumatic brain injury (TBI). Design. Two-arm, single-blinded, parallel-group, randomized, controlled trial with a blinded assessment. Setting. Trauma intensive care unit at a university hospital. Participants. Forty consecutive patients on mechanical ventilation (MV) secondary to TBI were prospectively recruited within the first 24 hours following admission. Interventions. (The intervention group (NMES; n = 20) received a daily session of NMES on the rectus femoris muscle for five consecutive days (55 min/each session). The control group (n = 20) received usual care. Main Outcome Measures. Muscle echogenicity and thickness were evaluated by ultrasonography. A daily blood sample was collected to assess circulating levels of insulin-like growth factor I (IGF-I), inflammatory cytokines, and matrix metalloproteinases (MMP). Results. Both groups were similar at baseline. A smaller change in muscle echogenicity and thickness (difference between Day 1 and Day 7) was found in the control group compared to the NMES group (29.9 +/- 2.1 vs. 3.0 +/- 1.2, p < 0.001; -0.79 +/- 0.12 vs. -0.01 +/- 0.06, p < 0.001, respectively). Circulating levels of IGF-I, pro-inflammatory cytokines (IFN-y), and MMP were similar between groups. Conclusion. An early NMES protocol can preserve muscle size and quality and maintain systemic levels of signaling mediators of muscle growth and inflammation in patients with TBI. (is trial is registered with https://www.ensaiosclinicos.gov.br under number RBR-2db. | Notes: | Cipriano, G (corresponding author), Univ Brasilia, Fac Ceilandia, Sci & Technol Hlth Program PPGCTS, Brasilia, DF, Brazil.; Cipriano, G (corresponding author), UniEVANGEL, Human Movement & Rehabil Program, Anapolis, GO, Brazil.; Cipriano, G (corresponding author), Univ Brasilia, Fac Ceilandia, Rehabil Sci Program PPGCR, Brasilia, DF, Brazil. lutavernard@gmail.com; pauloeugenio.bsb@gmail.com; priscillaflavia@yahoo.com.br; viniciusmaldaner@gmail.com; joaodurigan@gmail.com; marqueti@gmail.com; otavionobrega@unb.br; sunita.mathur@utoronto.ca; chris.burtin@uhasselt.be; fabriciobarin@gmail.com; wilcellym@gmail.com; shrramalho@gmail.com; gaspar.chiappa@gmail.com; ftnadiagomes@gmail.com; cscarval@usp.br; grafb@unb.br; cipriano@unb.br |
Document URI: | http://hdl.handle.net/1942/41521 | ISSN: | 2090-1305 | e-ISSN: | 2090-1313 | DOI: | 10.1155/2023/9335379 | ISI #: | 001043418300001 | Rights: | 2023 Luciana Vieira et al.This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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CCRP9335379 1..12.pdf | Published version | 507.9 kB | Adobe PDF | View/Open |
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