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Title: | Moderate- and High-Intensity Endurance Training Alleviate Diabetes-Induced Cardiac Dysfunction in Rats | Authors: | D'HAESE, Sarah VERBOVEN, Maxim EVENS, Lize DELUYKER, Dorien LAMBRICHTS, Ivo OP 'T EIJNDE, Bert HANSEN, Dominique BITO, Virginie |
Issue Date: | 2023 | Publisher: | MDPI | Source: | Nutrients, 15 (18) (Art N° 3950) | Abstract: | Exercise training is an encouraging approach to treat cardiac dysfunction in type 2 diabetes (T2DM), but the impact of its intensity is not understood. We aim to investigate whether and, if so, how moderate-intensity training (MIT) and high-intensity interval training (HIIT) alleviate adverse cardiac remodeling and dysfunction in rats with T2DM. Male rats received standard chow (n = 10) or Western diet (WD) to induce T2DM. Hereafter, WD rats were subjected to a 12-week sedentary lifestyle (n = 8), running MIT (n = 7) or HIIT (n = 7). Insulin resistance and glucose tolerance were assessed during the oral glucose tolerance test. Plasma advanced glycation end-products (AGEs) were evaluated. Echocardiography and hemodynamic measurements evaluated cardiac function. Underlying cardiac mechanisms were investigated by histology, western blot and colorimetry. We found that MIT and HIIT lowered insulin resistance and blood glucose levels compared to sedentary WD rats. MIT decreased harmful plasma AGE levels. In the heart, MIT and HIIT lowered end-diastolic pressure, left ventricular wall thickness and interstitial collagen deposition. Cardiac citrate synthase activity, mitochondrial oxidative capacity marker, raised after both exercise training modalities. We conclude that MIT and HIIT are effective in alleviating diastolic dysfunction and pathological cardiac remodeling in T2DM, by lowering fibrosis and optimizing mitochondrial capacity. | Notes: | Bito, V (corresponding author), UHasselt, Biomed Res Inst, Cardio & Organ Syst COST, B-3590 Diepenbeek, Belgium. sarah.dhaese@uhasselt.be; virginie.bito@uhasselt.be |
Keywords: | stype 2 diabetes;Western diet;exercise training;diastolic dysfunction;adverse cardiac remodeling | Document URI: | http://hdl.handle.net/1942/41667 | e-ISSN: | 2072-6643 | DOI: | 10.3390/nu15183950 | ISI #: | 001072238200001 | Rights: | 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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